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Article
The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer1,2. Here we studied the effects of hotspot gain-o...
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Article
Open AccessWidespread parainflammation in human cancer
Chronic inflammation has been recognized as one of the hallmarks of cancer. We recently showed that parainflammation, a unique variant of inflammation between homeostasis and chronic inflammation, strongly pro...
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Article
Inflammatory networks underlying colorectal cancer
Inflammation is one of the hallmarks of cancer. Ben-Neriah and colleagues review the inflammatory networks underlying colorectal cancer.
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Article
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and colleagues show that these structures can instead nurture ...
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Article
Inflammation meets cancer, with NF-κB as the matchmaker
Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary rel...
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Article
Epithelial microRNAs regulate gut mucosal immunity via epithelium–T cell crosstalk
Normal gut–immune system homeostasis requires interactions among epithelial cells, lymphocytes and host microflora. Ben-Neriah and colleagues show that defined microRNA expression in the gut mucosa is also imp...
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Article
CKIα ablation highlights a critical role for p53 in invasiveness control
In a mouse model of intestinal cancer, Yinon Ben-Neriah and colleagues show that in the absence of CK1-α, the loss of p53 dramatically enhances tumour progression and metastasis. The tumour repressor p53 norma...
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Chapter and Conference Paper
Design and Synthesis of Backbone Cyclic Phosphopeptides: The IκB Model
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Article
Epithelial NF-κB maintains host gut microflora homeostasis
Epithelial NF-κB preserves the integrity of the gut epithelial barrier and coordinates the antimicrobial actions of the innate and adaptive immune systems. Deficiency in or hyperactivation of this transcriptio...
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Article
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
The mechanisms by which commensal bacteria suppress inflammatory signalling in the gut are still unclear. Here, we present a cellular mechanism whereby the polarity of intestinal epithelial cells (IECs) has a ...
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Article
NF-κB functions as a tumour promoter in inflammation-associated cancer
The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, the latter accou...
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Article
Behind the scenes of anergy: a tale of three E3s
Anergy induction initiates a transcription program involving the upregulation of several ubiquitin ligases (E3s). New data show how these E3s contribute to the establishment of anergy.
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Article
Regulatory functions of ubiquitination in the immune system
Protein modification via covalent attachment of ubiquitin has emerged as one of the most common regulatory processes in all eukaryotes; it is possibly second only to phosphorylation. In fact, ubiquitination and p...
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Article
High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-κB activation
Based on the essential involvement of NF-κB in immune and inflammatory responses and its apoptosis-rescue function in normal and malignant cells, inhibitors of this transcription factor are potential therapeut...
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Article
Identification of the receptor component of the IκBα–ubiquitin ligase
NF-κB, a ubiquitous, inducible transcription factor involved in immune, inflammatory, stress and developmental processes, is retained in a latent form in the cytoplasm of non-stimulated cells by inhibitory mol...
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Article
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
INDUCIBLE gene expression in eukaryotes is mainly controlled by the activity of transcriptional activator proteins, such as NF-κB (refs 1–3), a factor activated upon treatment of cells with phorbolesters, lipo...
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Article
Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain
Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation1. The protein-tyrosine kinases described to date are either transmembrane prote...
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Article
Isolation and expression of a complementary DNA that confers multidrug resistance
The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in v...
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Chapter and Conference Paper
Structural Modification of c-abl in Lymphoma and Leukemia
Vertebrate DNA contains a gene, named c-abl, that was disclosed by a rapidly oncogenic retrovirus, Abelson murine leukemia virus (A-MuLV)- A-MuLV carries a portion of c-abl (Goff et al., 1980) including a region ...
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Chapter
Normal and Transforming N-Terminal Variants of c-abl
V-abl was first described as the oncogene contained in Abelson murine leukemia virus (A-MuLV), a virus that transforms both lymphocytes and fibroblast lines. The v-abl gene product has a pro...
