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Article
Open AccessIntravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer
Limited understanding of the cancer biology of metastatic sites is a major factor contributing to poor outcomes in cancer patients. The regional lymph nodes are the most common site of metastasis in most solid...
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Article
Open AccessErratum to: “A novel role for ezrin in breast cancer angio/lymphangiogenesis”
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Article
Open AccessA novel role for ezrin in breast cancer angio/lymphangiogenesis
Recent evidence suggests that tumour lymphangiogenesis promotes lymph node metastasis, a major prognostic factor for survival of breast cancer patients. However, signaling mechanisms involved in tumour-induced...
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Article
Open AccessActivated Stat5 levels do not increase with cell density in contrast to activated Stat3 levels in breast epithelial cell culture
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Article
Open AccessEzrin is required for adhesion and migration in invasive breast cancer
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Article
Open AccessEzrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells
The membrane cytoskeletal crosslinker, ezrin, a member of the ERM family of proteins, is frequently over-expressed in human breast cancers, and is required for motility and invasion of epithelial cells. Our gr...
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Article
Open AccessA novel activating role of SRC and STAT3 on HGF transcription in human breast cancer cells
We have previously determined that the HGF promoter can be transactivated by a combination of activated Src and wild-type Stat3 in the mouse breast cell lines HC11 and SP1. To determine if this pathway is of r...
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Article
Open AccessThe membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells
The membrane cytoskeletal crosslinker ezrin participates in several functions including cell adhesion, motility and cell survival, and there is increasing evidence that it regulates tumour progression. However...
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Tumor specific antigens induced by mutagens and DNA hypomethylating agents: implications for the immunobiology of neoplasia
The effusive enthusiasm that characterized so much of tumor immunology research during the 1960’s and 1970’s has gradually given way to a widespread and pervasive cynicism. One could cite many reasons for this...
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Article
Receptor specificity, functional characteristics, and cell-surface phenotype of a highly selected anti-I-Ab-specific, long-term T-cell line
A highly selected alloreactive T-cell line was developed by repeated restimulation of B10.D2/n lymph-node cells with irradiated C57BL/10Sn (BIO) spleen cells in long-term MLC for up to 2 1/2 years. Continuous ...
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Article
Antigen-binding receptors on T cells from long-term MLR. Evidence of binding sites for allogeneic and self-MHC products
Antibody inhibition of radiolabelled stimulator membrane vesicle binding by T blasts activated in the mixed lymphocyte reaction (MLR) was used to identify responder-cell determinants involved in the binding ph...
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Article
Alloactivated Lyt 1 +2− T lymphoblasts bind syngeneic Ia antigens
A large proportion of T blasts activated in the mixed lymphocyte reaction (MLR) is capable of binding plasma membrane (PM) vesicles prepared from the stimulator strain1,2. The binding of vesicles is specific, and...
