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  1. Article

    Open Access

    An optimized bioluminescent substrate for non-invasive imaging in the brain

    Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical events in vivo and thus has become an indispensable technique in biomedical research. However, BLI in the central nervou...

    Yichi Su, Joel R. Walker, Mary P. Hall, Mark A. Klein, **ang Wu… in Nature Chemical Biology (2023)

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    Article

    Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals

    Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a brigh...

    Yichi Su, Joel R. Walker, Yunhee Park, Thomas P. Smith, Lan **ang Liu… in Nature Methods (2020)