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  1. No Access

    Article

    Machine Learning Opportunities in Flight Test: Preflight Checks

    Flight test for aircraft certification is a fundamental method to ensure safe aircraft and air travel worldwide. Flight test data is collected through a limited number of discrete subspace points in the flight...

    Joel R. Walker, David Claudio in SN Computer Science (2024)

  2. Article

    Open Access

    An optimized bioluminescent substrate for non-invasive imaging in the brain

    Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical events in vivo and thus has become an indispensable technique in biomedical research. However, BLI in the central nervou...

    Yichi Su, Joel R. Walker, Mary P. Hall, Mark A. Klein, **ang Wu… in Nature Chemical Biology (2023)

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  3. Article

    Open Access

    Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

    Modulation of protein abundance using tag-Targeted Protein Degrader (tTPD) systems targeting FKBP12F36V (dTAGs) or HaloTag7 (HaloPROTACs) are powerful approaches for preclinical target validation. Interchanging t...

    Christoph Grohmann, Charlene M. Magtoto, Joel R. Walker… in Nature Communications (2022)

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  4. No Access

    Article

    Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals

    Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a brigh...

    Yichi Su, Joel R. Walker, Yunhee Park, Thomas P. Smith, Lan **ang Liu… in Nature Methods (2020)