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Article
Open AccessDifferential responses of SARS-CoV-2 variants to environmental drivers during their selective sweeps
Previous work has shown that environmental variables affect SARS-CoV-2 transmission, but it is unclear whether different strains show similar environmental responses. Here we leverage genetic data on the trans...
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Article
Open AccessHigh-throughput characterization of bacterial responses to complex mixtures of chemical pollutants
Our understanding of how microbes respond to micropollutants, such as pesticides, is almost wholly based on single-species responses to individual chemicals. However, in natural environments, microbes experien...
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Article
Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals
Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a brigh...
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Article
Open AccessCommunity-level respiration of prokaryotic microbes may rise with global warming
Understanding how the metabolic rates of prokaryotes respond to temperature is fundamental to our understanding of how ecosystem functioning will be altered by climate change, as these micro-organisms are majo...
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Article
Maternal metabolic response to dietary treatment for impaired glucose tolerance and gestational diabetes mellitus
Dietary advice is a standard component of treatment for pregnant women with impaired glucose tolerance (IGT) and gestational diabetes (GDM), yet few studies report glycemic profiles in response to dietary ther...
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Article
Open AccessHorizontal gene transfer in bdelloid rotifers is ancient, ongoing and more frequent in species from desiccating habitats
Although prevalent in prokaryotes, horizontal gene transfer (HGT) is rarer in multicellular eukaryotes. Bdelloid rotifers are microscopic animals that contain a higher proportion of horizontally transferred, n...
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Article
Technology Insight: measuring prolactin in clinical samples
The measurement of prolactin levels is commonly requested for patients with reproductive disorders. This Review describes the causes of hyperprolactinemia and the steps to take once it is suspected. In particu...
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Article
The epidermolytic (exfoliative) toxins of Staphylococcus aureus
Two epidermolytic toxins, produced by different strains of Staphylococcus aureus, split human skin at a site in the upper epidermis. Clinical effects are most common in infants, but adults are susceptible. Epider...
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Article
Immunofluorescence localization of the epidermolytic toxin target in mouse epidermal cells and tissue
An epidermolytic toxin target was observed in keratohyalin granules of sectioned epidermis by a ‘direct’ fluorescence procedure using FTC-toxin, but not by an ‘indirect’ procedure using sequential reaction wit...
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Article
The binding of epidermolytic toxin fromStaphylococcus aureus to mouse epidermal tissue
Fluorescein-labelled epidermolytic toxin (FTC-toxin) ofStaphylococcus aureus and ferritin—toxin conjugate have been prepared and purified. FTC-toxin bound selectively to cryostat and resin-impregnated sections of...
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Article
Morphine enhancement of shuttle avoidance prevented by α-methyltyrosine
Rats were given 6 days of training (180 trials) to make a two-way (shuttle) avoidance response. “Poor performers” making less than 50% avoidances in the 6th block of 30 trials were given drug treatments on the...
