6 Result(s)
within
Yedukondalu Nalli
Biomedicine
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Article
Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis
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Article
Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis
The comprehensive anti-cancer activities of cannabinoid acids and non-cannabinoids are not fully explored. Herein we report simple extraction, faster bioassay-guided fractionation, and HPLC-assisted purificati...
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Article
Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents
While screening for potential anti-inflammatory natural product scaffolds, alantolactone (1) was found to attenuate LPS-induced pro-inflammatory mediators in RAW264.7 macrophage cells. In this regard, a series of...
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Article
Isolation, structural modification of macrophin from endophytic fungus Phoma macrostoma and their cytotoxic potential
Four known metabolites, macrophin (1), rosellisin (2), 2-(2-hydroxy-5-6-methoxy-3-methylene-1,4-benzodioxin-2(3H)-one (3), and methoxyphenoxyacrylic acid (4) were isolated, for the first time, from an endophytic ...
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Article
Isolation of three new metabolites and intervention of diazomethane led to separation of compound 1 & 2 from an endophytic fungus, Cryptosporiopsis sp. depicting cytotoxic activity
The discovery of three new natural products (1, 4, and 5), one semi-synthetic derivative (3) along with two known compounds (2 and 6) were isolated from an endophytic fungus Cryptosporiopsis sp. The structural el...
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Article
TNF-α and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp
Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines. The anti-inflammatory cytokines are a series of immune regulatory molecules that control...
