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Article
Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis
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Article
Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their in-silico analysis
The comprehensive anti-cancer activities of cannabinoid acids and non-cannabinoids are not fully explored. Herein we report simple extraction, faster bioassay-guided fractionation, and HPLC-assisted purificati...
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Article
Dactylides A−C, three new bioactive 22-membered macrolides produced by Dactylosporangium aurantiacum
Three new 22-membered polyol macrolides, dactylides A−C (1−3), were isolated from Dactylosporangium aurantiacum ATCC 23491 employing repeated chromatographic separations, and their structures were established bas...
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Article
A Secondary Metabolite of Cercospora sp., Associated with Rosa damascena Mill., Inhibits Proliferation, Biofilm Production, Ergosterol Synthesis and Other Virulence Factors in Candida albicans
Here we describe the antimicrobial potential of secondary metabolites, fulvic acid (F.A.) and anhydrofulvic acid (AFA), produced by RDE147, an endophyte of Rosa damascena Mill. The endophyte was identified as Cer...
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Article
Biodiversity and antimicrobial potential of bacterial endophytes from halophyte Salicornia brachiata
Extreme natural habitats like halophytes, marsh land, and marine environment are suitable arena for chemical ecology between plants and microbes having environmental impact. Endophytes are an ecofriendly optio...
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Article
Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents
While screening for potential anti-inflammatory natural product scaffolds, alantolactone (1) was found to attenuate LPS-induced pro-inflammatory mediators in RAW264.7 macrophage cells. In this regard, a series of...
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Article
Isolation, structural modification of macrophin from endophytic fungus Phoma macrostoma and their cytotoxic potential
Four known metabolites, macrophin (1), rosellisin (2), 2-(2-hydroxy-5-6-methoxy-3-methylene-1,4-benzodioxin-2(3H)-one (3), and methoxyphenoxyacrylic acid (4) were isolated, for the first time, from an endophytic ...
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Article
Porostereum sp., Associated with Saffron (Crocus sativus L.), is a Latent Pathogen Capable of Producing Phytotoxic Chlorinated Aromatic Compounds
Saffron (Crocus sativus L.) is one of the most expensive spices in the world due to its medicinal and aromatic value. However, saffron production is severely affected by the corm rot disease throughout the saffro...
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Article
Isolation of three new metabolites and intervention of diazomethane led to separation of compound 1 & 2 from an endophytic fungus, Cryptosporiopsis sp. depicting cytotoxic activity
The discovery of three new natural products (1, 4, and 5), one semi-synthetic derivative (3) along with two known compounds (2 and 6) were isolated from an endophytic fungus Cryptosporiopsis sp. The structural el...
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Article
An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte
Muscodor spp. are proficient producers of bioactive volatile organic compounds (VOCs) with many potential applications. However, all members of this genus produce varying amounts and type...
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Article
TNF-α and IL-6 inhibitory effects of cyclic dipeptides isolated from marine bacteria Streptomyces sp
Inflammation is mediated by a variety of soluble factors, including a group of secreted polypeptides known as cytokines. The anti-inflammatory cytokines are a series of immune regulatory molecules that control...
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Article
Antimicrobial Potential of Thiodiketopiperazine Derivatives Produced by Phoma sp., an Endophyte of Glycyrrhiza glabra Linn.
During the screening of endophytes obtained from Glycyrrhiza glabra Linn., the extract from a fungal culture designated as GG1F1 showed significant antimicrobial activity. The fungus was identified as a species o...
