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Open AccessAssociation between atherosclerosis and height loss among older individuals
Atherosclerosis and height loss are each reportedly associated with cardiovascular disease. However, no studies have found an association between atherosclerosis and height loss. A retrospective study of 2435 ...
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Article
Open AccessAssociation between anti-thyroid peroxidase antibody and thyroid stimulating hormone: a cross-sectional study
To maintain normal level of thyroid hormone, especially for free thyroxine (FT4), individuals with latent thyroid gland damage might have required higher thyroid stimulating hormone (TSH) than those without la...
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Article
Endoscopic mucosal ischemic index for predicting anastomotic complications after esophagectomy: a prospective cohort study
Postoperative complications related to gastric conduit reconstruction are still common issues after McKeown esophagectomy. A novel endoscopic mucosal ischemic index is desired to predict anastomotic complicati...
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Article
Prognostic significance of NY-ESO-1 antigen and PIGR expression in esophageal tumors of CHP-NY-ESO-1-vaccinated patients as adjuvant therapy
The aim of this study was to determine the efficacy and the biomarkers of the CHP-NY-ESO-1 vaccine complexed with full-length NY-ESO-1 protein and a cholesteryl pullulan (CHP) in patients with esophageal squam...
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Open AccessAssociation between circulating CD34-positive cell count and height loss among older men
Height loss starting in middle age is reportedly significantly associated with death due to cardiovascular disease. Impaired blood flow is the main pathology in cardiovascular disease. Hematopoietic stem cells...
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Article
Open AccessInfrared Thermography with High Accuracy in a Neonatal Incubator
As the accuracy of body temperature measurement is especially critical in premature infants on admission to the neonatal intensive care unit (NICU), noninvasive measurement using infrared thermography (IRT) ha...
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Article
Open AccessVascular endothelial growth factor (VEGF) polymorphism rs3025039 and atherosclerosis among older with hypertension
Angiogenesis inhibition therapy causes hypertension by increasing peripheral vascular resistance. Vasa vasorum angiogenesis plays a crucial role in the development of atherosclerosis. Since vascular endothelia...
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Article
Open AccessAssociation between thyroid-stimulating hormone (TSH) and proteinuria in relation to thyroid cyst in a euthyroid general population
High normal levels of thyroid-stimulating hormone (TSH) have been reported to be associated with chronic kidney disease (CKD) among euthyroid individuals. However, there has been only limited research on the a...
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Open AccessAssociation between height-related polymorphism rs17081935 and reduced handgrip strength in relation to status of atherosclerosis: a cross-sectional study
Aging is a process that increases oxidative stress. Increased oxidative stress leads to the development of atherosclerosis and mitochondrial dysfunction. Mitochondria contribute to energy production that might...
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Open AccessAssociation between thyroid cysts and hypertension by atherosclerosis status: a cross-sectional study
Our recent studies indicate that thyroid cysts have clinical implications. Thyroid cysts could have a positive effect on the supply of thyroid hormones. Both hyperthyroidism and hypothyroidism cause hypertensi...
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Open AccessAssociations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study
A positive association between handgrip strength and blood pressure has been reported. Since these factors are linked to the condition of the endothelium, the activity of endothelial repair might influence the...
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Article
Open AccessThe VH framework region 1 as a target of efficient mutagenesis for generating a variety of affinity-matured scFv mutants
In vitro affinity-maturation potentially generates antibody fragments with enhanced antigen-binding affinities that allow for develo** more sensitive diagnostic systems and more effective therapeutic agents....
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Open AccessContribution of VEGF polymorphism rs3025020 to short stature and hypertension in elderly Japanese individuals: a cross-sectional study
Recently, short stature has been revealed to be positively associated with hypertension, possibly because this indicates lower activity of vascular maintenance, such as angiogenesis. Vascular endothelial growt...
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Article
Open AccessPossible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population
Human T-cell leukemia virus type 1 (HTLV-1) activates inflammatory cascades by activating the NF-κB pathway. The minor allele of single nucleotide polymorphism (SNP) in breast cancer suppressor BRCA1-associated p...
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Article
Open AccessAssociation between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study
Serum sodium concentration within the normal range could act as an indicator of age-related changes such as decrease in muscle strength and impairment of capillary function. Since endothelial injury stimulates...
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Article
Open AccessAssociation between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women
Osteoporosis and related fractures, a worldwide public health issue of growing concern, is characterized by compromised bone strength and an increased risk of fracture. Here we show an association between self...
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Open AccessAssociations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study
The absence of thyroid cysts may indicate latent thyroid damage, as demonstrated in our previous study. However, the association between the absence of thyroid cysts and latent functional damage of the thyroid...
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Article
Open AccessPotential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population
Minor allele frequency (MAF) of rs3782886 (BRAP) and rs671 (ALDH2) are reported to be inversely associated with blood pressure. Another study revealed that hematopoietic activity which is evaluated by reticulo...
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Article
Open AccessCirculating CD34+ cells and active arterial wall thickening among elderly men: A prospective study
Age-related physical changes, such as low-grade inflammation and increased oxidative stress, induce endothelial repair and cause active arterial wall thickening by stimulating the production of CD34+ cells (th...
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Article
Open AccessAnti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study
Anti-thyroid peroxidase antibody (TPO-Ab) has been shown to cause autoimmune thyroiditis by inducing a deleterious influence on thyroid hormone synthesis. Further, thyroglobulin, which has an important role in...
