7 Result(s)

Article

Global fungal-host interactome map** identifies host targets of candidalysin

Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...

Tian-Yi Zhang, Yao-Qi Chen, **g-Cong Tan, **-An Zhou… in Nature Communications (2024)

Article

Vasa Vasorum Hypoperfusion Is Responsible for Medial Hypoxia and Anatomic Remodeling in the Newborn Lamb Ductus Arteriosus

Postnatal constriction of the full-term ductus arteriosus produces hypoxia of the muscle media. This is associated with anatomic remodeling (including smooth muscle death) that prevents subsequent reopening. W...

Hiroki Ka**o, Seth Goldbarg, Christine Roman, Bao Mei Liu… in Pediatric Research (2002)

Article

Combined Prostaglandin and Nitric Oxide Inhibition Produces Anatomic Remodeling and Closure of the Ductus Arteriosus in the Premature Newborn Baboon

After birth, the full-term ductus arteriosus actively constricts and undergoes extensive histologic changes that prevent subsequent reopening. These changes are thought to occur only if a region of intense hyp...

Steven R Seidner, Yao Qi Chen, Patricia R Oprysko, Francoise Mauray… in Pediatric Research (2001)

Article

The Role of Hypoxia in Ductus Closure and Reopening

Hiroki Ka**o, Yao Qi Chen, Nahid Waleh, Cameron J Koch… in Pediatric Research (1999)

Article

Permanent Anatomic Closure of the Ductus Arteriosus in Newborn Baboons: The Roles of Postnatal Constriction, Hypoxia, and Gestation

Permanent closure of the ductus arteriosus require loss of cells from the muscle media and development of neointimal mounds, composed in part of proliferating endothelial cells. We hypothesized that postnatal ...

Ronald I Clyman, Cecilia Y Chan, Françoise Mauray, Yao Qi Chen… in Pediatric Research (1999)

Article

Regulation of Ductus Arteriosus Patency by Nitric Oxide in Fetal Lambs: The Role of Gestation, Oxygen Tension, and Vasa Vasorum

We hypothesized that nitric oxide (NO) production by the fetal ductus arteriosus is limited because of low fetal PO₂, but that at neonatal PO₂, NO might be an important regulator of ductus arteriosus tone. We exp...

Ronald I Clyman, Nahid Waleh, Stephen M Black, R Kirk Riemer… in Pediatric Research (1998)

Article

Changes in Endothelial Cell and Smooth Muscle Cell Integrin Expression during Closure of the Ductus Arteriosus: An Immunohistochemical Comparison of the Fetal, Preterm Newborn, and Full-Term Newborn Rhesus Monkey Ductus

Anatomical closure of the ductus arteriosus requires normally quiescent luminal endothelial cells and medial smooth muscle cells to migrate into the subendothelial space forming intimal mounds that eventually ...

Ronald I Clyman, Boyd W Goetzman, Yao Qi Chen, Françoise Mauray… in Pediatric Research (1996)