32 Result(s)

Article

Anatomic Closure of the Premature Patent Ductus Arteriosus: The Role of CD14⁺/CD163⁺ Mononuclear Cells and VEGF in Neointimal Mound Formation

Permanent closure of the newborn ductus arteriosus requires the development of neointimal mounds to completely occlude its lumen. VEGF is required for neointimal mound formation. The size of the neointimal mou...

Nahid Waleh, Steven Seidner, Donald McCurnin, Luis Giavedoni… in Pediatric Research (2011)

Article

Chronic In Utero Cyclooxygenase Inhibition Alters PGE2-Regulated Ductus Arteriosus Contractile Pathways and Prevents Postnatal Closure

Although prostaglandin E2 (PGE2) vasodilates the ductus arteriosus, tocolysis with cyclooxygenase (COX) inhibitors delays postnatal ductus arteriosus closure. We used fetal mice and sheep to determine whether ...

Jeff Reese, Nahid Waleh, Stanley D Poole, Naoko Brown… in Pediatric Research (2009)

Article

Oxygen-Induced Tension in the Sheep Ductus Arteriosus: Effects of Gestation on Potassium and Calcium Channel Regulation

Compared with the full-term ductus arteriosus, the premature ductus is less likely to constrict when exposed to postnatal oxygen concentrations. We used isolated fetal sheep ductus arteriosus (pretreated with ...

Nahid Waleh, Jeff Reese, Hiroki Ka**o, Christine Roman… in Pediatric Research (2009)

Article

The Effects of Caffeine on the Preterm Sheep Ductus Arteriosus

Caffeine and other methyl xanthines are widely used in the neonatal period. A recent, randomized, placebo-controlled, multicenter trial found that infants who were randomly assigned to caffeine treatment had l...

Ronald I Clyman, Christine Roman in Pediatric Research (2007)

Article

ATP Depletion and Cell Death in the Neonatal Lamb Ductus Arteriosus

Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops A...

Max Levin, Seth Goldbarg, Anders Lindqvist, Karl Swärd… in Pediatric Research (2005)

Article

The Role of Monocyte-Derived Cells and Inflammation in Baboon Ductus Arteriosus Remodeling

Inflammatory processes play a crucial role in the pathogenesis of atherosclerosis and other vascular disorders. We hypothesized that ischemia of the ductus arteriosus might initiate an active inflammatory resp...

Nahid Waleh, Steven Seidner, Donald McCurnin, Bradley Yoder… in Pediatric Research (2005)

Article

Effects of Hypoxia, Hypoglycemia, and Muscle Shortening on Cell Death in the Sheep Ductus Arteriosus

After birth, constriction of the full-term ductus arteriosus produces ischemic hypoxia, caspase activation, DNA fragmentation (>70% of cell nuclei are positive by the terminal deoxynucleotidyl transferase nick...

Seth Goldbarg, Timothy Quinn, Nahid Waleh, Christine Roman… in Pediatric Research (2003)

Article

Vasa Vasorum Hypoperfusion Is Responsible for Medial Hypoxia and Anatomic Remodeling in the Newborn Lamb Ductus Arteriosus

Postnatal constriction of the full-term ductus arteriosus produces hypoxia of the muscle media. This is associated with anatomic remodeling (including smooth muscle death) that prevents subsequent reopening. W...

Hiroki Ka**o, Seth Goldbarg, Christine Roman, Bao Mei Liu… in Pediatric Research (2002)

Article

Perinatal Myocardial DNA and Protein Changes in the Lamb: Effect of Cortisol in the Fetus

Myocardial growth during fetal life is accomplished by proliferation of the number of myocytes (hyperplasia). Shortly after birth, normal growth of the heart is predominantly due to increase in cell size (hype...

Abraham M Rudolph, Christine Roman, Veronique Gournay in Pediatric Research (1999)

Article

Effect of β-Adrenergic Stimulation on Oxygen Metabolism in the Fetal Lamb

Catecholamines, which are released into the circulation during stress, increase fetal metabolism. This effect appears to be related to β-adrenoreceptor stimulation. We examined the effect of isoproterenol infu...

Véronique A Gournay, Christine Roman, Abraham M Rudolph in Pediatric Research (1999)

Article

Mechanisms of Adrenomedullin-Induced Increase of Pulmonary Blood Flow in Fetal Sheep

Mechanisms of adrenomedullin-induced increases in fetal pulmonary blood flow were examined in 19 near-term fetal sheep using four key blocker drugs: nitric oxide synthase inhibitor (N^ω-nitro-L-arginine), calciton...

Yasushi Takahashi, Maartje De Vroomen, Veronique Gournay… in Pediatric Research (1999)

Article

Adrenomedullin Blocks Closure of the Ductus Arteriosus in Newborn Lambs.† 144

Yasushi Takahashi, Ronald I Clyman, Christine Roman… in Pediatric Research (1998)

Article

Effects of Maternal Oxygen Administration on the Ductus Arteriosus and Pulmonary Circulation in Fetal Sheep. 129

Meera Narayanan, Yasushi Takahashi, Christine Roman… in Pediatric Research (1998)

Article

Endogenous Calcitonin Gene-related Peptide (CGRP) is not Involved in the Initial Increase in Pulmonary Blood Flow due to Oxygen Ventilation in Fetal Lambs 1754

Yasushi Takahashi, Christine Roman, Michael A Heymann in Pediatric Research (1998)

Article

Nitric Oxide Inhibits Closure of the Ductus Arteriosus following Antenatal Exposure to Indomethacin † 982

Ronald I Clyman, Sylvan Chemtob, Michael A Heymann, Christine Roman in Pediatric Research (1998)

Article

Endothelin Receptor Blockade Does Not Alter Closure of the Ductus Arteriosus• 332

Jeffrey R Fineman, Yasushi Takahashi, Christine Roman… in Pediatric Research (1998)

Article

Calcitonin Gene-related Peptide Increases Pulmonary Blood Flow in Fetal Sheep. † 1602

Yasushi Takahashi, Maartje De Vroomen, Christine Roman… in Pediatric Research (1997)

Article

Mechanisms of Adrenomedullin-induced Increase in Pulmonary Blood Flow in Fetal Sheep. ♦ 1601

Yasushi Takahashi, Maartje De Vroomen, Veronique Gournay… in Pediatric Research (1997)

Article

Adrenomedullin Increases Pulmonary Blood Flow in Fetal Sheep

We studied the effects of exogenously administered adrenomedullin on fetal pulmonary arterial blood flow in near-term fetal sheep. The hemodynamic effects of a single injection of adrenomedullin into the left ...

Maartje De Vroomen, Yasushi Takahashi, Veronique Gournay… in Pediatric Research (1997)

Article

ADRENOMEDULLIN IS A PULMONARY VASODILATOR IN THE FETAL LAMB. • 1981

Veronique A Gournay, Christine Roman, Michael A Heymann… in Pediatric Research (1996)