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  1. No Access

    Article

    Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer

    Severe combined immunodeficiency (SCID) patients with an inactivating mutation in recombination activation gene 1 (RAG1) lack B and T cells due to the inability to rearrange immunoglobulin (Ig) and T-cell recepto...

    K Pike-Overzet, M Rodijk, Y-Y Ng, M R M Baert, C Lagresle-Peyrou, A Schambach… in Leukemia (2011)

  2. No Access

    Article

    Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK

    X-linked agammaglobulinemia (XLA) is the most common primary immunodeficiency (PID) in man and caused by mutations in the Bruton’s tyrosine kinase (BTK) gene. XLA is characterized by a B-cell differentiation arre...

    Y Y Ng, M R M Baert, K Pike-Overzet, M Rodijk, M H Brugman, A Schambach, C Baum… in Leukemia (2010)

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    Article

    Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients

    BCR–ABL fusion proteins show increased signaling through their ABL tyrosine kinase domain, which can be blocked by specific inhibitors, thereby providing effective treatment. This makes detection of BCR–ABL aberr...

    F Weerkamp, E Dekking, Y Y Ng, V H J van der Velden, H Wai, S Böttcher… in Leukemia (2009)

  4. No Access

    Article

    Sola dosis facit venenum. Leukemia in gene therapy trials: a question of vectors, inserts and dosage?

    In clinical gene therapy trials for X-linked severe combined immunodeficiency, the development of leukemia has come up as a severe adverse effect. In all five cases, T-cell acute lymphoblastic leukemia (T-ALL)...

    F J T Staal, K Pike-Overzet, Y Y Ng, J J M van Dongen in Leukemia (2008)

  5. Article

    Association of hospital and surgeon operation volume with the incidence of postoperative endophthalmitis: Taiwan experience

    To determine the association between hospital and surgeon volume with the incidence of postoperative endophthalmitis.

    Y-T Fang, L-N Chien, Y-Y Ng, H-F Chu, W-M Chen, C-Y Cheng, S-C Wu in Eye (2006)

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    Chapter

    In Vitro Magnetic Resonance Scanning of Urinary Calculi

    Clinical experience with ESWL has shown that the size and composition of urinary calculi affect success. Knowing the composition of a stone before treatment is therefore desirable. We have examined the role of...

    N. P. Cohen, H. N. Whitfield, G. Dolke, Y. Y. Ng, P. Armstrong in Urolithiasis 2 (1994)

  7. No Access

    Article

    Parotid haemangioma in infants: MR imaging at 1.5T

    Parotid gland neoplasms are uncommon and account for less than 2% of human tumours. Haemangiomas account for about 50% of parotid tumours in infants and children compared to only 2% in adults. As the clinical ...

    Dr. C. D. George, Y. Y. Ng, M. A. Hall-Craggs, B. M. Jones in Pediatric Radiology (1991)