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Article
Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study
The mechanisms underlying major depressive disorder (MDD) in children and adolescents are unclear. Metabolomics has been utilized to capture metabolic signatures of various psychiatric disorders; however, urin...
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Article
Open AccessIdentifying plasma metabolic characteristics of major depressive disorder, bipolar disorder, and schizophrenia in adolescents
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) are classified as major mental disorders and together account for the second-highest global disease burden, and half of these pat...
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Article
Open AccessAKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies ha...
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Article
Open AccessA Clinical Predictive Nomogram for Traumatic Brain Parenchyma Hematoma Progression
Acute traumatic intraparenchymal hematoma (tICH) expansion is a major cause of clinical deterioration after brain contusion. Here, an accurate prediction tool for acute tICH expansion is proposed.
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Article
Open AccessComparative short-term efficacy and acceptability of a combination of pharmacotherapy and psychotherapy for depressive disorder in children and adolescents: a systematic review and meta-analysis
Although the clinical efficacy and safety of combination of pharmacotherapy and psychotherapy in the treatment of depressive disorders in children and adolescents have been studied, the results remain controve...
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Article
Open AccessBiogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior
Most previous studies in the pathophysiology of major depressive disorder (MDD) focused on fecal samples, which limit the identification of the gut mucosal and luminal microbiome in depression. Here, we addres...
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Article
Open AccessCorrection to: Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01251-8
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Article
Open AccessChronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys
Adolescent depression is a common and serious mental disorder with unique characteristics that are distinct from adult depression. The adult non-human primate stress-induced model of depressive-like behavior i...
