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Chapter
Microbiota-Gut-Brain Axis and Antidepressant Treatment
In the treatment of depressive disorders, conventional antidepressant therapy has been the mainstay of clinical management, along with well-established nonpharmacological interventions such as various kinds of...
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Article
Open AccessAKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models
Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies ha...
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Article
Open AccessThe gut microbiome in social anxiety disorder: evidence of altered composition and function
The microbiome-gut-brain axis plays a role in anxiety, the stress response and social development, and is of growing interest in neuropsychiatric conditions. The gut microbiota shows compositional alterations ...
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Article
Open AccessFeed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population
The impact of diet on the microbiota composition and the role of diet in supporting optimal mental health have received much attention in the last decade. However, whether whole dietary approaches can exert ps...
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Chapter
Gut Microbes: The Gut Brain Connection
A growing appreciation for the role of the gut microbiome in health and disease, coupled with recent advances in microbiome-related research, has emphasized the importance of the gut microbiota in regulating b...
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Article
Open AccessThe serotonin receptor 3E variant is a risk factor for female IBS-D
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT3 receptor family. 5-HT3Rs are encoded by HTR3 genes and...
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Article
Open AccessMicrobial-derived metabolites as a risk factor of age-related cognitive decline and dementia
A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identify...
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Article
Open AccessThe blood-brain barrier in aging and neurodegeneration
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwante...
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Article
Diet and depression: future needs to unlock the potential
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Article
Open AccessBiogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior
Most previous studies in the pathophysiology of major depressive disorder (MDD) focused on fecal samples, which limit the identification of the gut mucosal and luminal microbiome in depression. Here, we addres...
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Article
Reporting guidelines for human microbiome research: the STORMS checklist
The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a ch...
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Article
The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies
The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emergin...
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Chapter
The Microbiome-Gut-Brain Axis: A New Window to View the Impact of Prenatal Stress on Early Neurodevelopment
Prenatal maternal stress that results from general and pregnancy-specific forms of anxiety and depression, ranging in severity from everyday hassles to experiences of traumatic events, adversely impacts neurod...
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Article
Diet and depression: exploring the biological mechanisms of action
The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and ...
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Article
Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome
Male middle age is a transitional period where many physiological and psychological changes occur leading to cognitive and behavioural alterations, and a deterioration of brain function. However, the mechanism...
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Article
Open AccessDistinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse
Mounting evidence suggests a role for the gut microbiota in modulating brain physiology and behaviour, through bi-directional communication, along the gut-brain axis. As such, the gut microbiota represents a p...
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Article
Open AccessLongitudinal relationship of amino acids and indole metabolites with long-term body mass index and cardiometabolic risk markers in young individuals
Amino acid metabolites in biofluids are associated with high body mass index (BMI) and cardiometabolic abnormalities. However, prospective investigations regarding these associations are few, particularly amon...
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Article
Open AccessMetabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction
Stress negatively impacts gut and brain health. Individual differences in response to stress have been linked to genetic and environmental factors and more recently, a role for the gut microbiota in the regula...
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Article
Open AccessPsychotropics and the Microbiome: a Chamber of Secrets…
The human gut contains trillions of symbiotic bacteria that play a key role in programming different aspects of host physiology in health and disease. Psychotropic medications act on the central nervous system...
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Article
Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function
Growing evidence supports a role for the microbiota in regulating gut-brain interactions and, thus, psychiatric disorders. Despite substantial scientific efforts to delineate the mechanism of action of psychot...
