Social Inequalities in Health in Nonhuman Primates
The Biology of the Gradient
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Female baboon adrenal zona fasciculata and zona reticularis regulatory and functional proteins decrease across the life course
Debate exists on life-course adrenocortical zonal function trajectories. Rapid, phasic blood steroid concentration changes, such as circadian rhythms and acute stress responses, complicate quantification. To a...
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Executive function mediates age-related variation in social integration in female vervet monkeys (Chlorocebus sabaeus)
In humans, social participation and integration wane with advanced age, a pattern hypothesized to stem from cognitive or physical decrements. Similar age-related decreases in social participation have been ob...
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Open AccessCross-species comparative analysis of single presynapses
Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based method, synaptometry by time of flight (SynTOF), we ap...
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Correction to: Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
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Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
Dual declines in gait speed and cognitive performance are associated with increased risk of develo** dementia. Characterizing the patterns of such impairments therefore is paramount to distinguishing healthy...
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Open AccessDiet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model
The objective of this study was to increase understanding of the complex interactions between diet, obesity, and the gut microbiome of adult female non-human primates (NHPs). Subjects consumed either a Western (n
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Open AccessCorrection to: Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys
A Correction to this paper has been published: https://doi.org/10.1038/s41398-021-01251-8
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Open AccessChronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys
Adolescent depression is a common and serious mental disorder with unique characteristics that are distinct from adult depression. The adult non-human primate stress-induced model of depressive-like behavior i...
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Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates
Depression is the most common mental health problem in aging persons and is a leading risk factor for physical disability, especially in women. Though antidepressant drugs such as serotonin reuptake inhibitors...
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Erratum to: Multi-Atlas Library for Eliminating Normalization Failures in Non-Human Primates
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Microbial translocation and skeletal muscle in young and old vervet monkeys
Intestinal barrier dysfunction leads to microbial translocation (MT) and inflammation in vertebrate and invertebrate animal models. Age is recently recognized as a factor leading to MT, and in some human and a...
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Multi-Atlas Library for Eliminating Normalization Failures in Non-Human Primates
Current tools for automated skull strip**, normalization, and segmentation of non-human primate (NHP) brain MRI studies typically demonstrate high failure rates. Many of these failures are due to a poor init...
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Social Status and the Non-human Primate Brain
Social status hierarchies are a central facet of life for numerous species. Much is known about the effects of social rank on the behavior and physiology of these species, yet the neurobiological effects have ...
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Dietary Modification of Physiological Responses to Chronic Psychosocial Stress: Implications for the Obesity Epidemic
The scientific community has been working feverishly on the problem of obesity, particularly since the Surgeon’s General’s 2001 call to action to prevent and decrease obesity.
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Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys
Although widely prescribed, little is known about the effects of selective serotonin reuptake inhibitors (SSRIs) on social behavior and cerebrospinal fluid (CSF) monoamines in female primates.
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Aging and physical mobility in group-housed Old World monkeys
While indices of physical mobility such as gait speed are significant predictors of future morbidity/mortality in the elderly, mechanisms of these relationships are not understood. Relevant animal models of ag...
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Social Stress and Cardiovascular Disease in Primates
Atherosclerosis of the coronary arteries (CAA) and its complications are the principal pathological processes that result in coronary heart disease (CHD). Cynomolgus monkeys (Macaca fascicularis) are a well-char...
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Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis)
The effects of chronic moderate alcohol consumption on cardiac function are not understood. Acute stress may affect cardiac function by shifting autonomic cardiac regulation in favor of the sympathetic nervous...
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Effects of long-term moderate alcohol consumption on agonistic and affiliative behavior of socially housed female cynomolgus monkeys (Macaca fascicularis)
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