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Article
Open AccessTobacco cessation among smokers under substance use treatment for alcohol and/or cannabis: study protocol and pilot study
Approximately 80% of people with a substance use disorder (SUD) are smokers. Starting SUD treatment offers the opportunity to also quit smoking. The ACT-ATAC project aims to identify the predictors associated ...
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Article
Open AccessPan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3′ UTR ends via alternative polyadenylation c...
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Article
Open AccessBCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells
The differentiation of human pluripotent stem cells into pancreatic cells involves cellular proliferation and apoptosis during cell fate transitions. However, their implications for establishing cellular ident...
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Article
Open AccessViable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches
Here, we describe an expansion of the typical DNA size limitations associated with CRISPR knock-in technology, more specifically, the physical extent to which mouse genomic DNA can be replaced with donor (in t...
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Chapter and Conference Paper
Automatic Learning of Background Semantics in Generic Surveilled Scenes
Advanced surveillance systems for behavior recognition in outdoor traffic scenes depend strongly on the particular configuration of the scenario. Scene-independent trajectory analysis techniques statistically ...
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Article
Open AccessAntisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
Apolipoprotein B (APOB) is an integral part of the LDL, VLDL, IDL, Lp(a) and chylomicron lipoprotein particles. The APOB pre-mRNA consists of 29 constitutively-spliced exons. APOB exists as two natural isoforms: ...
