![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Metabolomic and genetic architecture of gestational diabetes subtypes
Physiological gestational diabetes mellitus (GDM) subtypes that may confer different risks for adverse pregnancy outcomes have been defined. The aim of this study was to characterise the metabolome and genetic...
-
Article
Open AccessHigher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile
Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such ...
-
Article
Correction to: Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
A Correction to this paper has been published: https://doi.org/10.1007/s00125-021-05421-7
-
Article
Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
We aimed to examine associations of newborn anthropometric measures with childhood glucose metabolism with the hypothesis that greater newborn birthweight, adiposity and cord C-peptide are associated with high...
-
Article
Metabolomic and genetic associations with insulin resistance in pregnancy
Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance.
-
Article
Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study
Maternal type 2 diabetes during pregnancy and gestational diabetes are associated with childhood adiposity; however, associations of lower maternal glucose levels during pregnancy with childhood adiposity, ind...
-
Article
Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads.
-
Article
Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes
Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediat...
-
Chapter
Diabetes Mellitus
Diabetes mellitus is characterized by fasting and postprandial hyperglycemia. Type 1 diabetes occurs secondary to autoimmune destruction of the insulin-secreting pancreatic β-cells, whereas type 2 diabetes res...
-
Chapter
Diabetes Mellitus
Diabetes mellitus affects approximately 5% of the general population with its prevalence varying between ethnic groups and geographic regions. The majority of cases are accounted for by two different types of ...
-
Chapter
Cytokines
Cytokines encompass diverse groups of multifunctional proteins that play key roles in a variety of biological processes, including cell growth and activation, inflammation, immunity, hematopoiesis, tumorigenes...
-
Chapter
Mechanisms of Hormone Action
Hormones provide a form of communication between different cells and from one organ to another. The dramatic effects of hormones on physiologic functions such as growth and metabolism have allowed relatively s...