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Article
Metabolomic and genetic architecture of gestational diabetes subtypes
Physiological gestational diabetes mellitus (GDM) subtypes that may confer different risks for adverse pregnancy outcomes have been defined. The aim of this study was to characterise the metabolome and genetic...
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Article
Open AccessIntegrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes
Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear.
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Article
Open AccessRefining the diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis
Perinatal outcomes vary for women with gestational diabetes mellitus (GDM). The precise factors beyond glycemic status that may refine GDM diagnosis remain unclear. We conducted a systematic review and meta-an...
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Article
Urinary metal profiles in mother-offspring pairs and their association with early dysglycemia in the International Hyperglycemia and Adverse Pregnancy Outcome Follow Up Study (HAPO-FUS)
Variations in dietary intake and environmental exposure patterns of essential and non-essential trace metals influence many aspects of human health throughout the life span.
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Article
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes ...
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Article
Open AccessEarly emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study
Leukocyte telomere length (LTL) is suggested to be a biomarker of biological age and reported to be associated with metabolic diseases such as type 2 diabetes. Glucose metabolic traits including glucose and in...
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Article
Open AccessCorrection: Path-level interpretation of Gaussian graphical models using the pair-path subscore
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Article
Pandemic-related barriers to the success of women in research: a framework for action
Women in academia have fallen behind with publications and grant funding during the COVID-19 pandemic and risk drop** out of the research workforce altogether, unless urgent action is taken by institutes and...
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Article
Open AccessPath-level interpretation of Gaussian graphical models using the pair-path subscore
Construction of networks from cross-sectional biological data is increasingly common. Many recent methods have been based on Gaussian graphical modeling, and prioritize estimation of conditional pairwise depen...
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Article
Open AccessHigher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile
Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such ...
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Article
Correction to: Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
A Correction to this paper has been published: https://doi.org/10.1007/s00125-021-05421-7
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Article
Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study: newborn anthropometrics and childhood glucose metabolism
We aimed to examine associations of newborn anthropometric measures with childhood glucose metabolism with the hypothesis that greater newborn birthweight, adiposity and cord C-peptide are associated with high...
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Article
Metabolomic and genetic associations with insulin resistance in pregnancy
Our study aimed to integrate maternal metabolic and genetic data related to insulin sensitivity during pregnancy to provide novel insights into mechanisms underlying pregnancy-induced insulin resistance.
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Article
Open AccessVariants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, ...
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Article
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide associatio...
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Article
Maternal glucose levels during pregnancy and childhood adiposity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study
Maternal type 2 diabetes during pregnancy and gestational diabetes are associated with childhood adiposity; however, associations of lower maternal glucose levels during pregnancy with childhood adiposity, ind...
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Article
Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries
We aimed to determine the association of maternal metabolites with newborn adiposity and hyperinsulinaemia in a multi-ethnic cohort of mother–newborn dyads.
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Article
Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes
Maternal obesity increases the risk for large-for-gestational-age birth and excess newborn adiposity, which are associated with adverse long-term metabolic outcomes in offspring, probably due to effects mediat...
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Article
Open AccessMixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data
Metabolomics offers a unique integrative perspective for health research, reflecting genetic and environmental contributions to disease-related phenotypes. Identifying robust associations in population-based o...
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Article
Genetics of Gestational Diabetes Mellitus and Maternal Metabolism
Gestational diabetes mellitus (GDM) is defined as abnormal glucose tolerance with onset or first recognition during pregnancy. Women with a history of GDM are at long-term risk for develo** type 2 diabetes (...
