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Article
Open AccessA cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription
The essential G1-cyclin, CCND1, is frequently overexpressed in cancer, contributing to tumorigenesis by driving cell-cycle progression. D-type cyclins are rate-limiting regulators of G1-S progression in mammalian...
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Article
Open AccessThe DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses
Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities. The DACH1 gene encodes a winged helix/Forkhead DNA-binding p...
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Article
Open AccessRegulation of ERα-dependent breast cancer metastasis by a miR-29a signaling
Malignant breast cancer (BC) remains incurable mainly due to the cancer cell metastasis, which is mostly related to the status of Estrogen receptor alpha (ERα). However, our understanding of the mechanisms thr...
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Article
Open AccessCorrection: DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
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Protocol
Assays for the Spectrum of Circulating Tumor Cells
Cancer cells sharing stem cell properties are called “cancer stem cells” (CSCs). CSCs have distinct metabolic properties, are intrinsically drug resistant evading chemotherapies, are regulated by miRNA network...
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Article
Open AccessLeronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy
Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled recep...
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Article
Open AccessThe membrane-associated form of cyclin D1 enhances cellular invasion
The essential G1-cyclin, CCND1, is a collaborative nuclear oncogene that is frequently overexpressed in cancer. D-type cyclins bind and activate CDK4 and CDK6 thereby contributing to G1–S cell-cycle progression. ...
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Article
Open AccessCyclin D1 integrates G9a-mediated histone methylation
Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, an...
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Article
Open AccessDACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
C-X-C motif ligand 8 (CXCL8), known as a proinflammatory chemokine, exerts multiple effects on the proliferation, invasion, and migration of tumor cells via the autocrine or paracrine manner. Conversely, the h...
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Chapter
D-Type Cyclins and Gene Transcription
D-type cyclins contribute the regulatory subunits to the holoenzymes that phosphorylate distinct substrates and regulate diverse biological processes, including cellular proliferation and differentiation. A gr...
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Article
Open AccessRecent advances of bispecific antibodies in solid tumors
Cancer immunotherapy is the most exciting advancement in cancer therapy. Similar to immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T), bispecific antibody (BsAb) is attracting more and mo...
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Article
Open AccessDACH1 suppresses breast cancer as a negative regulator of CD44
Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles ...
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Article
Open AccessRecent advances of highly selective CDK4/6 inhibitors in breast cancer
Uncontrolled cell division is the hallmark of cancers. Full understanding of cell cycle regulation would contribute to promising cancer therapies. In particular, cyclin-dependent kinases 4/6 (CDK4/6), which ar...
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Article
Erratum: Cancer metabolism: a therapeutic perspective
Nat. Rev. Clin. Oncol. 14, 11–31 (2017); doi:10.1038/nrclinonc.2016.60 Owing to a typesetting error, the final line of text in Box 3, and the abbreviation lists for Tables 2 and 3 were omitted from the print a...
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Article
Open AccessSmall RNA zippers lock miRNA molecules and block miRNA function in mammalian cells
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed ‘small RNA zipper’. It is design...
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Reference Work Entry In depth
Cell Cycle-Related Kinases
Cyclin proteins are regulatory subunits of a holoenzyme, which together with CDKs, phosphorylate key substrates to modulate cellular physiology and drive cell cycle progression. At least 13 human CDKs have bee...
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Article
Cancer metabolism: a therapeutic perspective
The metabolic ecology of tumours enables component cells to generate ATP, maintain redox balance, and undertake biosynthesis, which in turn support tumour prog...
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Article
Open AccessCancer stem cell metabolism
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointi...
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Protocol
Breast Cancer Stem Cell Isolation
Cells within the tumor are highly heterogeneous. Only a small portion of the cells within the tumor is capable to generate a new tumor. These cells are called cancer stem cells. Theoretically, cancer stem cell...
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Living Reference Work Entry In depth
Cell Cycle-Related Kinases
Cyclin proteins are regulatory subunits of a holoenzyme, which together with CDKs, phosphorylate key substrates to modulate cellular physiology and drive cell cycle progression. At least 13 human CDKs have bee...
