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  1. No Access

    Article

    Genetic Pathways Regulating Glutamate Levels in Retinal Müller Cells

    Müller cells serve many functions including the regulation of extracellular glutamate levels. The product of two genes, Slc1a3 [aka solute carrier family 1 (glial high affinity glutamate transporter), member 3] a...

    Monica M. Jablonski, Natalie E. Freeman, William E. Orr… in Neurochemical Research (2011)

  2. No Access

    Article

    The Effects of a Cd81 Null Mutation on Retinal Pigment Epithelium in Mice

    The present study examines the effects of Cd81-null mutation on the development of the retinal pigment epithelium (RPE), specifically cell size and number of cells with multiple nuclei. The outlines of RPE in ret...

    Ye Pan, David F. Geisert, William E. Orr, Eldon E. Geisert in Neurochemical Research (2011)

  3. No Access

    Article

    Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents

    Novel tetrahydroisoquinoline (THI) analogs were designed, synthesized, and their antiglioma activity was evaluated. The results showed that 6,8-dimethoxy-1-(2′-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroiso...

    Renukadevi Patil, Shivaputra Patil, **angDi Wang, Fei Ma… in Medicinal Chemistry Research (2011)

  4. Article

    Open Access

    Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush

    Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influ...

    Justin P Templeton, Mohamed Nassr, Felix Vazquez-Chona… in BMC Neuroscience (2009)

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  5. No Access

    Article

    Plasma and cerebrospinal fluid pharmacokinetics of the novel tetrahydroisoquinoline EDL-155 in rats

    Tetrahydroisoquinolines (THIs) have demonstrated anti-cancer activity in rodent models of glioma, a form of brain cancer refractory to therapeutic intervention. In this study, peripheral and cerebrospinal flui...

    Pengfei Song, Fei Ma, Fan Wang, **angDi Wang… in Cancer Chemotherapy and Pharmacology (2008)

  6. Article

    Open Access

    A functional profile of gene expression in ARPE-19 cells

    Retinal pigment epithelium cells play an important role in the pathogenesis of age related macular degeneration. Their morphological, molecular and functional phenotype changes in response to various stresses....

    Rajesh K Sharma, William E Orr, Allyson D Schmitt, Dianna A Johnson in BMC Ophthalmology (2005)

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