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Article
Genetic Pathways Regulating Glutamate Levels in Retinal Müller Cells
Müller cells serve many functions including the regulation of extracellular glutamate levels. The product of two genes, Slc1a3 [aka solute carrier family 1 (glial high affinity glutamate transporter), member 3] a...
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Article
The Effects of a Cd81 Null Mutation on Retinal Pigment Epithelium in Mice
The present study examines the effects of Cd81-null mutation on the development of the retinal pigment epithelium (RPE), specifically cell size and number of cells with multiple nuclei. The outlines of RPE in ret...
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Article
Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents
Novel tetrahydroisoquinoline (THI) analogs were designed, synthesized, and their antiglioma activity was evaluated. The results showed that 6,8-dimethoxy-1-(2′-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroiso...
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Article
Open AccessDifferential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush
Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influ...
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Article
Plasma and cerebrospinal fluid pharmacokinetics of the novel tetrahydroisoquinoline EDL-155 in rats
Tetrahydroisoquinolines (THIs) have demonstrated anti-cancer activity in rodent models of glioma, a form of brain cancer refractory to therapeutic intervention. In this study, peripheral and cerebrospinal flui...
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Article
Open AccessA functional profile of gene expression in ARPE-19 cells
Retinal pigment epithelium cells play an important role in the pathogenesis of age related macular degeneration. Their morphological, molecular and functional phenotype changes in response to various stresses....