Skip to main content

14 Result(s)

within Monica M. Jablonski Remove this filter

and

  1. No Access

    Chapter and Conference Paper

    A Novel Mouse Model for Late-Onset Retinal Degeneration (L-ORD) Develops RPE Abnormalities Due to the Loss of C1qtnf5/Ctrp5

    Late-onset retinal degeneration (L-ORD) is an autosomal dominant macular dystrophy resulting from mutations in the gene CTRP5/C1QTNF5. A mouse model (Ctrp5+/−) for the most common S163R developed many features of...

    Shyamanga Borooah, Anil Chekuri, Shikha Pachauri… in Retinal Degenerative Diseases XIX (2023)

  2. No Access

    Chapter and Conference Paper

    Current Advancements in Mouse Models of Retinal Disease

    The field of retinal degenerative (RDs) disease study has been in a state of exponential growth from discovering the underlying genetic components of such diseases as age-related macular degeneration (AMD) and...

    T. J. Hollingsworth, **angdi Wang, Raven N. Simpson… in Retinal Degenerative Diseases XIX (2023)

  3. No Access

    Article

    P-glycoprotein Restricts Ocular Penetration of Loperamide across the Blood-Ocular Barriers: a Comparative Study in Mdr1a Knock-out and Wild Type Sprague Dawley Rats

    The current research was undertaken to determine the existence and magnitude of P-glycoprotein (P-gp) expression on the blood-ocular barriers by studying the ocular penetration of loperamide, a specific P-gp s...

    Akshaya Tatke, Karthik Yadav Janga, Bharathi Avula, **angDi Wang… in AAPS PharmSciTech (2018)

  4. Article

    Open Access

    Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

    Glaucoma is a multi-factorial blinding disease in which genetic factors play an important role. Elevated intraocular pressure is a highly heritable risk factor for primary open angle glaucoma and currently the...

    Sumana R. Chintalapudi, Doaa Maria, **ang Di Wang… in Nature Communications (2017)

    Download PDF (2258 KB) View Article

  5. No Access

    Article

    Nimodipine Ophthalmic Formulations for Management of Glaucoma

    Preparation and evaluation of topical ophthalmic formulations containing nimodipine-CD complexes prepared using HP-β-CD, SBE-β-CD and M-β-CD for the management of glaucoma.

    Doaa Nabih Maria, Abd-Elgawad Helmy Abd-Elgawad… in Pharmaceutical Research (2017)

  6. No Access

    Protocol

    Systems Genetics Analysis to Identify the Genetic Modulation of a Glaucoma-Associated Gene

    Loss of retinal ganglion cells (RGCs) is one of the hallmarks of retinal neurodegenerative diseases, glaucoma being one of the most common. Recently, γ-synuclein (SNCG) was shown to be highly expressed in the ...

    Sumana R. Chintalapudi, Monica M. Jablonski in Systems Genetics (2017)

  7. No Access

    Article

    Novel Endogenous Glycan Therapy for Retinal Diseases: Safety, In Vitro Stability, Ocular Pharmacokinetic Modeling, and Biodistribution

    Asialo, tri-antennary oligosaccharide (NA3 glycan) is an endogenous compound, which supports proper folding of outer segment membranes, promotes normal ultrastructure, and maintains protein expression patterns...

    Shankar Swaminathan, Huiling Li, Mallika Palamoor… in The AAPS Journal (2014)

  8. No Access

    Article

    Novel Topical Ophthalmic Formulations for Management of Glaucoma

    Preparation of topical ophthalmic formulations containing brimonidine-loaded nanoparticles prepared from various biodegradable polymers—PCL, PLA and PLGA—for sustained release of brimonidine as a once daily re...

    Mohammed M. Ibrahim, Abd-Elgawad H. Abd-Elgawad… in Pharmaceutical Research (2013)

  9. No Access

    Article

    Genetic Pathways Regulating Glutamate Levels in Retinal Müller Cells

    Müller cells serve many functions including the regulation of extracellular glutamate levels. The product of two genes, Slc1a3 [aka solute carrier family 1 (glial high affinity glutamate transporter), member 3] a...

    Monica M. Jablonski, Natalie E. Freeman, William E. Orr… in Neurochemical Research (2011)

  10. No Access

    Article

    Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice

    With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenoty** mice carrying new mutations in...

    Dabney K. Johnson, Eugene M. Rinchik, Naima Moustaid-Moussa, Darla R. Miller… in AGE (2005)

  11. No Access

    Chapter and Conference Paper

    The Intact Xenopus Laevis Eye Rudiment: A Quasi-In Vivo System for the Study of Retinal Development and Degenerations

    The purpose of this chapter is to demonstrate the validity and value of the “quasi-in vivo” intact eye culture system fromXenopus laevistadpoles as a model for the study of retinal development and degenerations.

    Monica M. Jablonski in Retinal Degenerations (2003)

  12. No Access

    Article

    Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development

    The differentiation of neuronal cells in the develo** mammalian retina is closely coupled to cell cycle arrest and proceeds in a highly organized manner. Cyclin D1, which regulates cell proliferation in many...

    Stephan X Skapek, Suh-Chin J Lin, Monica M Jablonski, Robyn N McKeller… in Oncogene (2001)

  13. No Access

    Article

    Investigating the mechanisms of retinal degenerations with antisense oligonucleotides

    Utilizing antisense oligonucleotides coupled with an intact Xenopus eye rudiment model, we have effectively demonstrated that we are able to downregulate the expression of a photoreceptor-specific protein, rds/pe...

    Monica M. Jablonski in Documenta Ophthalmologica (2001)

  14. No Access

    Chapter

    Antisense Inactivation of Rds/Peripherin in Xenopus Laevis Embryonic Retinal Cultures

    To investigate the role of rds/J.peripherin in photoreceptor outer segment membrane assembly, we have transfected embryonic Xenopus laevis retinas with phosphorothioated antisense or sense RNA complementary to sp...

    Vikas Kancherla, Wojciech Kedzierski… in Retinal Degenerative Diseases and Experime… (1999)