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Article
Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator
Ovarian cancer is a gynecologic malignancy with a high mortality rate. In the present study, we developed a novel cell-based vaccine, Meso-VAX, to generate mesothelin antigen-specific immune responses and immu...
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Article
High-frequency PIN–PMN–PT single crystal ultrasonic transducer for imaging applications
A high-frequency (∼60 MHz) ultrasonic transducer with a [001]-oriented 0.27Pb(In1/2Nb1/2)O3–0.45Pb(Mg1/3Nb2/3)O3–0.28PbTiO3 (PIN–PMN–PT) piezoelectric single crystal as an active element has been fabricated and c...
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Article
Noncarrier naked antigen-specific DNA vaccine generates potent antigen-specific immunologic responses and antitumor effects
Genetic immunization strategies have largely focused on the use of plasmid DNA with a gene gun. However, there remains a clear need to further improve the efficiency, safety, and cost of potential DNA vaccines...
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Article
Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism
A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which hinders their long-t...
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Article
CD8+ T cells, NK cells and IFN-γ are important for control of tumor with downregulated MHC class I expression by DNA vaccination
One of the major hurdles facing cancer immunotherapy is that cancers may downregulate expression of MHC class I molecules. The development of a suitable tumor model with downregulated MHC class I expression is...
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Article
Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen
Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns with DNA vaccines however, such...
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Article
Recombinant DNA vaccines protect against tumors that are resistant to recombinant vaccinia vaccines containing the same gene
Antigen-specific cancer immunotherapy involves the delivery of tumor-associated antigen to the host for the generation of tumor-specific immune responses and antitumor effects. We hypothesized that different d...