39 Result(s)

Article

Intravenous Nicotine Reduces Cerebral Glucose Metabolism: A Preliminary Study

Nicotine is self-administered by smoking tobacco products, and enhances positive mood (at least in smokers). Since most drugs of abuse decrease regional cerebral metabolic rate(s) for glucose (rCMRglc) in huma...

June M Stapleton, Stephen F Gilson, Dean F Wong… in Neuropsychopharmacology (2003)

Chapter and Conference Paper

MR-Less Surface-Based Amyloid Estimation by Subject-Specific Atlas Selection and Bayesian Fusion

For clinical evaluation, assessing amyloid deposition with PiB-PET is desirable without requiring MR acquisition and associated fusion/segmentation techniques. A useful clinical tool is to estimate PiB-PET aga...

Lu** Zhou, Olivier Salvado, Vincent Dore… in Medical Image Computing and Computer-Assis… (2012)

Article

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease

Victor L. Villemagne, William E. Klunk… in European Journal of Nuclear Medicine and M… (2012)

Article

¹⁸F-florbetaben Aβ imaging in mild cognitive impairment

¹⁸F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impai....

Kevin Ong, Victor L Villemagne, Alex Bahar-Fuchs… in Alzheimer's Research & Therapy (2013)

Article

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [¹⁸F]FEDAA1106

The activation of microglia, in general, and the upregulation of the translocator protein (18 kDa) (TSPO) system, in particular, are key features of neuroinflammation, of which the in vivo visualization and quant...

Akihiro Takano, Fredrik Piehl, Jan Hillert, Andrea Varrone, Sangram Nag… in EJNMMI Research (2013)

Article

Assessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies

The introduction of tau imaging agents such as ¹⁸F-THK523 offers new hope for the in vivo assessment of tau deposition in tauopathies such as Alzheimer’s disease (AD), where preliminary ¹⁸F-THK523-PET studies hav...

Michelle T Fodero-Tavoletti, Shozo Furumoto… in Alzheimer's Research & Therapy (2014)

Article

Imago Mundi, Imago AD, Imago ADNI

Since the launch in 2003 of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in the USA, ever growing, similarly oriented consortia have been organized and assembled around the world. The various accompl...

Victor L Villemagne, Seong Yoon Kim, Christopher C Rowe… in Alzheimer's Research & Therapy (2014)

Article

A ‘Disease Severity Index’ to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia

Subjective memory decline (SMD) is a heterogeneous condition. While SMD might be the earliest sign of Alzheimer’s disease (AD), it also occurs in aging and various neurological, medical, and psychiatric condit...

Daniel Ferreira, Farshad Falahati, Cecilia Linden, Rachel F. Buckley… in Scientific Reports (2017)

Article

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults

Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of develo** dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance ...

Simon M. Laws, Scott Gaskin, Amy Woodfield, Velandai Srikanth… in Scientific Reports (2017)

Article

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test ...

Steve Pedrini, Veer B. Gupta, Eugene Hone, James Doecke, Sid O’Bryant… in Scientific Reports (2017)

Article

¹⁸F-Florbetaben PET beta-amyloid binding expressed in Centiloids

The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and prognostic thresholds in clinical practice and rese...

Christopher C. Rowe, Vincent Doré… in European Journal of Nuclear Medicine and M… (2017)

Chapter and Conference Paper

A Framework to Objectively Identify Reference Regions for Normalizing Quantitative Imaging

The quantitative use of medical images often requires an intensity scaling with respect to the signal from a well-characterized anatomical region of interest. The choice of such a region often varies between s...

Amir Fazlollahi, Scott Ayton… in Medical Image Computing and Computer Assis… (2018)

Article

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the ...

Tenielle Porter, Samantha C. Burnham, Vincent Doré, Greg Savage… in Scientific Reports (2018)

Article

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in m...

Stephanie R. Rainey-Smith, Gavin N. Mazzucchelli… in Translational Psychiatry (2018)

Article

Author Correction: Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

In Figure 1 of this article as originally published, the chemical structure at bottom right was incorrectly labelled ¹⁸F-PM-PBB3. The text label has been corrected to ¹⁸F-PBB3 in the PDF and HTML versions of the ...

Victor L. Villemagne, Vincent Doré, Samantha C. Burnham… in Nature Reviews Neurology (2018)

Article

Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer’s disease (AD) risk. However, no study to-date has examined the relationship between MeD...

Stephanie R. Rainey-Smith, Yian Gu, Samantha L. Gardener… in Translational Psychiatry (2018)

Article

Centiloid scaling for quantification of brain amyloid with [¹⁸F]flutemetamol using multiple processing methods

A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a com...

Mark R. Battle, Lovena Chedumbarum Pillay, Val J. Lowe, David Knopman… in EJNMMI Research (2018)

Article

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of b...

Xavier Hadoux, Flora Hui, Jeremiah K. H. Lim, Colin L. Masters… in Nature Communications (2019)

Article

Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition

The accumulation of brain amyloid β (Aβ) is one of the main pathological hallmarks of Alzheimer’s disease (AD). However, the role of brain amyloid deposition in the development of AD and the genetic variants asso...

Michael Vacher, Tenielle Porter, Victor L. Villemagne, Lidija Milicic… in Scientific Reports (2019)

Article

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s disease

The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer...

Sanka Amadoru, Vincent Doré, Catriona A. McLean… in Alzheimer's Research & Therapy (2020)