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Article
Open AccessHealthcare consumer acceptability of routine use of the EQ-5D-5L in clinical care: a cross-sectional survey
Patient reported outcome measures, such as the EQ-5D-5L, provide a measure of self-perceived health status or health-related quality of life. Understanding the consumer acceptability of a patient reported outc...
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Article
Open AccessThe implementation of a perioperative medicine for older people undergoing surgery service: a qualitative case study
The international scale and spread of evidence-based perioperative medicine for older people undergoing surgery (POPS) services has not yet been fully realised. Implementation science provides a structured app...
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Article
Using a multi-stakeholder co-design process to develop a health service organisation-wide patient reported outcome measure collection system
Limited examples exist of successful Patient Reported Outcome Measure (PROM) implementation across an entire healthcare organisation. The aim of this study was to use a multi-stakeholder co-design process to d...
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Open AccessMulti-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance
Uncovering the functional relevance underlying verbal declarative memory (VDM) genome-wide association study (GWAS) results may facilitate the development of interventions to reduce age-related memory decline ...
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Article
Open AccessAcceptability of the routine use and collection of a generic patient reported outcome measure from the perspective of healthcare staff: a qualitative study
Patient-reported outcome measures (PROMs) provide a measure of self-perceived health status or health-related quality of life. They have been used to support provider-patient decisions, healthcare delivery, an...
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Article
Open AccessProspective application of theoretical implementation frameworks to improve health care in hospitals — a systematic review
Health Service implementation projects are often guided by theoretical implementation frameworks. Little is known about the effectiveness of these frameworks to facilitate change in processes of care and patie...
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Article
Open AccessA landscape assessment of the use of patient reported outcome measures in research, quality improvement and clinical care across a healthcare organisation
Patient reported outcome measures (PROMs) can be used by healthcare organisations to inform improvements in service delivery. However, routine collection of PROMs is difficult to achieve across an entire healt...
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Article
Open AccessAuthor Correction: Neuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample
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Open AccessNeuroimaging and cognitive correlates of retinal Optical Coherence Tomography (OCT) measures at late middle age in a twin sample
Sharing in embryology and function between the eye and brain has led to interest in whether assessments of the eye reflect brain changes seen in neurodegeneration. We aimed to examine the associations between ...
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Article
Open AccessDefining ICD-10 surrogate variables to estimate the modified frailty index: a Delphi-based approach
There are currently no validated globally and freely available tools to estimate the modified frailty index (mFI). The widely available and non-proprietary International Statistical Classification of Diseases ...
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Article
Open AccessComparison of the predictive ability of clinical frailty scale and hospital frailty risk score to determine long-term survival in critically ill patients: a multicentre retrospective cohort study
The Clinical Frailty Scale (CFS) is the most commonly used frailty measure in intensive care unit (ICU) patients. The hospital frailty risk score (HFRS) was recently proposed for the quantification of frailty....
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Open AccessRisk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis
To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid...
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Article
The Interdependence of Blood Pressure and Glucose in Vietnam
Modelling of associations of systolic blood pressure (BP) and blood glucose (BG) with their explanatory factors in separate regressions treats them as having independent biological mechanisms. This can lead to...
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Open Access5.1 The Role of Blood Pressure, Aortic Stiffness, and Haemodynamics in Brain Health in Older People with Type 2 Diabetes Mellitus
Type 2 diabetes (T2D) is associated with dementia, and abnormal blood pressure (BP), aortic stiffness, and haemodynamics. We aimed to study the contribution of such factors to brain structure and cognition, re...
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Article
Diabetes Therapies for Dementia
Type 2 diabetes (T2D) is a well-established risk factor for the development of dementia. Dementia and T2D share some underlying pathophysiology that has led to interest in the potential to repurpose drugs used...
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Gray matter volume covariance patterns associated with gait speed in older adults: a multi-cohort MRI study
Accelerated gait decline in aging is associated with many adverse outcomes, including an increased risk for falls, cognitive decline, and dementia. Yet, the brain structures associated with gait speed, and how...
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Open Access3.5 Cuff Blood Pressure is Progressively More Biased with Increasing Age: Individual Participant Level Analysis from the Inspect Consortium
Accurate blood pressure (BP) measurement is critical for appropriate hypertension diagnosis and management. Aortic BP represents pressure loading on vital organs and this can be approximated using upper arm cu...
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Open AccessInsulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of develo** dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance ...
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cogni...
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Open AccessNational survey of risk factors for non-communicable disease in Vietnam: prevalence estimates and an assessment of their validity
To estimate the prevalence of non-communicable disease (NCD) risk factors at a provincial level in Vietnam, and to assess whether the summary estimates allow reliable inferences to be drawn regarding regional ...
