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Article
Intravenous Nicotine Reduces Cerebral Glucose Metabolism: A Preliminary Study
Nicotine is self-administered by smoking tobacco products, and enhances positive mood (at least in smokers). Since most drugs of abuse decrease regional cerebral metabolic rate(s) for glucose (rCMRglc) in huma...
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Chapter and Conference Paper
MR-Less Surface-Based Amyloid Estimation by Subject-Specific Atlas Selection and Bayesian Fusion
For clinical evaluation, assessing amyloid deposition with PiB-PET is desirable without requiring MR acquisition and associated fusion/segmentation techniques. A useful clinical tool is to estimate PiB-PET aga...
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Article
Open AccessAβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease
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Article
Open Access18F-florbetaben Aβ imaging in mild cognitive impairment
18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impai....
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Article
Open AccessIn vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [18F]FEDAA1106
The activation of microglia, in general, and the upregulation of the translocator protein (18 kDa) (TSPO) system, in particular, are key features of neuroinflammation, of which the in vivo visualization and quant...
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Article
Open AccessAssessing THK523 selectivity for tau deposits in Alzheimer’s disease and non–Alzheimer’s disease tauopathies
The introduction of tau imaging agents such as 18F-THK523 offers new hope for the in vivo assessment of tau deposition in tauopathies such as Alzheimer’s disease (AD), where preliminary 18F-THK523-PET studies hav...
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Article
Open AccessImago Mundi, Imago AD, Imago ADNI
Since the launch in 2003 of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) in the USA, ever growing, similarly oriented consortia have been organized and assembled around the world. The various accompl...
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Article
Open AccessA ‘Disease Severity Index’ to identify individuals with Subjective Memory Decline who will progress to mild cognitive impairment or dementia
Subjective memory decline (SMD) is a heterogeneous condition. While SMD might be the earliest sign of Alzheimer’s disease (AD), it also occurs in aging and various neurological, medical, and psychiatric condit...
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Article
Open AccessInsulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults
Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of develo** dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance ...
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Article
Open AccessA blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort
Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test ...
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Article
Open Access18F-Florbetaben PET beta-amyloid binding expressed in Centiloids
The Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and prognostic thresholds in clinical practice and rese...
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Chapter and Conference Paper
A Framework to Objectively Identify Reference Regions for Normalizing Quantitative Imaging
The quantitative use of medical images often requires an intensity scaling with respect to the signal from a well-characterized anatomical region of interest. The choice of such a region often varies between s...
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Article
Open AccessKIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden
A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the ...
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Article
Open AccessGenetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden
The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in m...
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Article
Author Correction: Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions
In Figure 1 of this article as originally published, the chemical structure at bottom right was incorrectly labelled 18F-PM-PBB3. The text label has been corrected to 18F-PBB3 in the PDF and HTML versions of the ...
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Article
Open AccessMediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer’s disease (AD) risk. However, no study to-date has examined the relationship between MeD...
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Article
Open AccessCentiloid scaling for quantification of brain amyloid with [18F]flutemetamol using multiple processing methods
A standardised method for quantifying β-amyloid PET tracers would allow comparison across different tracers and different sites. The development of the Centiloid scale has aimed to achieve this, applying a com...
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Article
Open AccessNon-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease
Studies of rodent models of Alzheimer’s disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of b...
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Article
Open AccessValidation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
The accumulation of brain amyloid β (Aβ) is one of the main pathological hallmarks of Alzheimer’s disease (AD). However, the role of brain amyloid deposition in the development of AD and the genetic variants asso...
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Article
Open AccessComparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s disease
The Centiloid scale was developed to standardise the results of beta-amyloid (Aβ) PET. We aimed to determine the Centiloid unit (CL) thresholds for CERAD sparse and moderate-density neuritic plaques, Alzheimer...