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Article
Open AccessUrease-powered nanobots for radionuclide bladder cancer therapy
Bladder cancer treatment via intravesical drug administration achieves reasonable survival rates but suffers from low therapeutic efficacy. To address the latter, self-propelled nanoparticles or nanobots have ...
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Article
Open AccessLINE-1 regulates cortical development by acting as long non-coding RNAs
Long Interspersed Nuclear Elements-1s (L1s) are transposable elements that constitute most of the genome’s transcriptional output yet have still largely unknown functions. Here we show that L1s are required fo...
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Article
Open AccessEpigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures
Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (...
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Article
Open AccessLamin B1 map** reveals the existence of dynamic and functional euchromatin lamin B1 domains
Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nuc...
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Article
Open AccessDrosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration
Endoribonucleases participate in almost every step of eukaryotic RNA metabolism, acting either as degradative or biosynthetic enzymes. We previously identified the founding member of the Eukaryotic EndoU ribon...
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Article
TDP-43 Regulates the Microprocessor Complex Activity During In Vitro Neuronal Differentiation
TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein implicated in RNA metabolism at several levels. Even if ubiquitously expressed, it is considered as a neuronal activity-responsive factor and a maj...
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Article
Preoperative Chemotherapy Does Not Adversely Affect Pancreatic Structure and Short-Term Outcome after Pancreatectomy
Preoperative chemotherapy (PCHT) has recently been proposed also in patients with resectable pancreatic adenocarcinoma. Few data are currently available on the impact of PCHT on short-term postoperative outcom...
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Article
Learning curve for laparoscopic distal pancreatectomy in a high-volume hospital
Laparoscopic distal pancreatectomy (LDP) for benign and borderline pancreatic lesions is recently becoming the treatment of choice in experienced centres. No data have been published on learning curve so far. ...
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Surgical Treatment of the Pancreatic Stump: Comparing Different Techniques
The pancreatic stump is the major source of morbidity and mortality of pancreatoduodenectomy (PD). Any surgeon experienced in pancreatic surgery is often dealing with the dramatic consequences of the failure o...
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Chapter
Indications for Surgery and Surgical Procedures for Chronic Pancreatitis
In the management of chronic pancreatitis, pain has remained the main indication for surgical treatment over the years, but for a long time the high morbidity and mortality associated with pancreatic operation...
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Article
Analysis of Prognostic Factors Influencing Long-term Survival After Hepatic Resection for Metastatic Colorectal Cancer
The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for color...
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Article
Spleen-Preserving Distal Pancreatectomy with Excision of Splenic Artery and Vein: A Cautionary Note
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Article
Selective intra-graft apoptosis and down-regulation of lymphocyte bcl-2, iNOs and CD95L expression in kidney–pancreas transplanted patients after anti-Thymoglobulin induction
Intra-graft infiltrating cells apoptosis was evaluated in 20 consecutive kidney–pancreas transplanted (KP) patients without kidney rejection. Two fine-needle aspirated biopsy (FNAB) and two peripheral blood ly...
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Article
A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile
There are a large number of stable pancreatic ductal carcinoma cell lines (PDCL) that are used by researchers worldwide. Detailed data about their differentiation status and genetic alterations are present in ...
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Article
Successful endovascular treatment for gastroduodenal artery pseudoaneurysm with an arteriovenous fistula after pancreas transplantation
The aim of this study was to demonstrate the usefulness of endovascular treatment for gastroduodenal artery pseudoaneurysm with an arteriovenous fistula after simultaneous pancreas–kidney transplantation. We d...
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Article
Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers
Recent studies on small series of pancreatic cancer (PC) with foci of pancreatic intraepithelial neoplasia (PanIN), a putative precursor lesion, have shown that multiple K-RAS mutations may coexist in the same ne...
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Article
Generation and functional characterisation of dendritic cells from patients with pancreatic carcinoma with special regard to clinical applicability
Background: We studied dendritic cell (DC) function in patients affected by pancreatic carcinoma, and the possibility of obtaining DC adequate for immunological treatment modalities. Methods: Leucocytes were iso...
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Article
Pylorus-preserving Pancreaticoduodenectomy versus Conventional Whipple Operation
During 1990 to 1997 a series of 39 patients underwent a classic pancreaticoduodenectomy and 74 a pylorus-preserving pancreaticoduodenectomy for pancreatic adenocarcinoma. The two groups had similar tumor char...
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Article
Insulin secretory patterns and blood glucose homeostasis after islet allotransplantation in IDDM patients: comparison with segmental- or whole-pancreas transplanted patients through a long term longitudinal study
IDDM patients undergoing islet, segmental pancreas or whole pancreas allotransplantation were studied at regular intervals after surgery (3–6 months, 1, 2, 3 and 4 years) to evaluate glycometabolic control (24...
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Article
Evaluation of UICC TNM classification for pancreatic cancer
A different stage grou** of TNM factors can improve the predictivity of the UICC TNM classification for pancreatic cancer. Nevertheless, the Japanese Pancreas Society (JPS) classification maintains a higher ...
