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Early lung diffusion abnormalities and airways’ inflammation in children with type 1 diabetes
Type 1 diabetes (T1D) impacts lung function and exercise capacity in adults, but limited information is available in children. We hypothesize that T1D causes alterations in pulmonary function and cardiorespira...
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Open AccessAWARE A novel web application to rapidly assess cardiovascular risk in type 2 diabetes mellitus
To describe the development of the AWARE App, a novel web application for the rapid assessment of cardiovascular risk in Type 2 Diabetes Mellitus (T2DM) patients. We also tested the feasibility of using this A...
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Physical Activity and Inflammation
Diabetes mellitus, referred to simply as diabetes, is a serious metabolic disorder that affects millions of people worldwide [1, 2]. It is caused by defects in insulin production, insulin secretion, and insuli...
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Open AccessAbnormalities of the oculomotor function in type 1 diabetes and diabetic neuropathy
Abnormalities in the oculomotor system may represent an early sign of diabetic neuropathy and are currently poorly studied. We designed an eye-tracking-based test to evaluate oculomotor function in patients wi...
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Open AccessOne year of Hybrid Closed Loop on peritoneal dialysis: a case report
Automated insulin delivery is a game changer for type 1 diabetes treatment.
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Open AccessLiraglutide preserves CD34+ stem cells from dysfunction Induced by high glucose exposure
Glucagon like peptide-1 receptor agonists (GLP-1RAs) have shown to reduce mortality and cardiovascular events in patients with type 2 diabetes mellitus (T2DM). Since the impairment in number and function of va...
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Open AccessThe IGFBP3/TMEM219 pathway regulates beta cell homeostasis
Loss of pancreatic beta cells is a central feature of type 1 (T1D) and type 2 (T2D) diabetes, but a therapeutic strategy to preserve beta cell mass remains to be established. Here we show that the death recept...
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Imaging in experimental models of diabetes
Translational medicine, experimental medicine and experimental animal models, in particular mice and rats, represent a multidisciplinary field that has made it possible to achieve, in the last decades, importa...
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Open AccessContinuous glucose monitoring in patients with type 2 diabetes on hemodialysis
Diabetic kidney disease is the leading cause of end-stage kidney disease in high-income countries. The strict control of glycemic oscillations is the principal therapeutic target, but this could be hard to ach...
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Article
Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute respiratory syndrome coronavirus 2 infection may...
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Reply to letter to the editor regarding “Use of DPP-4 inhibitors in patients with COVID-19”
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Embryonic stem cell extracts improve wound healing in diabetic mice
Impaired wound healing significantly impacts morbidity and mortality in diabetic patients, necessitating the development of novel treatments to improve the wound healing process. We here investigated the topic...
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Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19
SARS–CoV-2 causes severe respiratory syndrome (COVID-19) with high mortality due to a direct cytotoxic viral effect and a severe systemic inflammation. We are herein discussing a possible novel therapeutic too...
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The β-cell effect of verapamil-based treatment in patients with type 2 diabetes: a systematic review
The possibility that verapamil has new beneficial effects in diabetic patients in terms of an improvement in glycometabolic control has been put forward recently in several studies. However, to date the issue ...
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Open AccessImmune heterogeneity of head and tail pancreatic lymph nodes in non-obese diabetic mice
The pancreatic lymph node is critical to the pathogenesis of autoimmune diabetes, as it constitutes the initial site for the priming of autoreactive T cells. In this study, we compared the histopathology of th...
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A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes
Chronic inflammation is postulated to be involved in the development of end-stage renal disease in diabetes, but which specific circulating inflammatory proteins contribute to this risk remain unknown. To stud...
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The impact of a successful treatment of hepatitis C virus on glyco-metabolic control in diabetic patients: a systematic review and meta-analysis
The effect of HCV eradication following the use of direct-acting antiviral drugs (DAAs) on the glyco-metabolic control is unknown. Through a meta-analysis of available clinical studies, we investigated whether...
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Duodenal adipose tissue is associated with obesity in baboons (Papio sp): a novel site of ectopic fat deposition in non-human primates
Ectopic fat is a recognized contributor to insulin resistance and metabolic dysfunction, while the role of fat deposition inside intestinal wall tissue remains understudied. We undertook this study to directly...
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Open AccessIschemia augments alloimmune injury through IL-6-driven CD4+ alloreactivity
Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI on antigen...
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Immunotherapy for type 1 diabetes
Although many approaches have been tested to overcome the insulin dependence caused by the pancreatic β-cells destruction observed in individuals affected by type 1 diabetes (T1D), medical research has largely...
