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Article
Study of the Association between Oxytocin Receptor Gene Polymorphism, Childhood Adversity, and Negative Symptoms of Schizophrenia
It is known that the neurohormone oxytocin plays an important role in the pathogenesis of mental illness and also models the relationship between stress factors, especially those acting in the early stages of ...
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Article
A Study of Association of the MIR137 VNTR rs58335419 with Schizophrenia
The MIR137 gene encodes microRNA-137 (miR-137), which is a brain-enriched miR that is highly expressed in various brain regions. miR-137 has been identified as a modulator of processes involved in the pathogenesi...
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Article
Effects of Oxytocin Pathway Gene Polymorphisms and Adverse Childhood Experiences on the Recognition of Emotion in Schizophrenia Spectrum Disorders
Objectives. To assess the role of interactions between oxytocin pathway gene polymorphisms and adverse childhood experiences (ACE) in deficits of the recognition of emotion in schizophrenia. Materials and methods
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Article
Genome-Wide Studies of the Comorbidity of Somatic and Mental Diseases
Studies of the genomic architecture of complex phenotypes, which include common somatic and mental diseases, have shown them to be characterized by high levels of polygenicity, i.e., there are large numbers of...
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Article
Association of the rs1344706 Polymorphism of the ZNF804A Gene with Induced EEG Rhythm Changes during Visual Perception of Verbal Stimuli in Healthy and Schizophrenic Subjects
The association of the rs1344706 polymorphism of the ZNF804A gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was stud...
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Article
Molecular-Genetic and Immunological Aspects of the Formation of Psychopathological Symptoms in Schizophrenia
This review presents data indicating that the formation of the psychopathological symptoms of schizophrenia is due to complex and diverse genetic factors associated with various functional and metabolic pathwa...
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Article
Genetic Polymorphism of Cytokines IL-1β, IL-4, and TNF-α as a Factor Modifying the Influence of Adverse Childhood Experiences on the Symptoms of Schizophrenia
Objectives. Working from the hypothesis that activation of the immune system is one of the mechanisms whereby early environmental factors influence the onset and course of schizophrenia, we studied the effects o...
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Article
Association of VNTR Polymorphism of the AS3MT Gene with the Risk of Schizophrenia
The AS3MT gene encodes arsenic(III) methyltransferase. VNTR polymorphism of the AS3MT gene is characteristic only for the human genome. It is associated with the expression of a human-specific AS3MTd2d3 protein i...
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Article
The CRP Gene’s Role in the Relations between Childhood Adversity and History of Suicide Attempts in Schizophrenia
Research suggests that, in contrast to circulating C-reactive protein (CRP), genetic variants conferring higher CRP levels have protective effects against schizophrenia and moderate influences of season of bir...
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Article
The Influence of Genotype on Phenotype in Contemporary Research into the Genetic Causes of Schizophrenia
The aim of the present review was to consider different approaches to establishing genotype–phenotype relationships in schizophrenia taking account of schizophrenia-specific mediating factors in the light of c...
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Article
Contemporary Genome-Wide Association Studies in Depression: The Critical Role of Phenoty**
The need to use large cohorts to identify genetic risk loci for mental disorders has led to the dilemma of phenoty** quality. This dilemma is particularly relevant to mental disorders common in the populatio...
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Article
Studies of the Relationship between Oxytocinergic System Genes, Perinatal Complications, and the Formation of Interpersonal Relationships in Schizophrenia Patients
Objectives. To identify any relationship between the genes of the oxytocinergic pathway and psychosocial functioning in schizophrenia, i.e., the ability of schizophrenia patients to form interpersonal relationsh...
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Article
Prognostication of Functional Outcomes of Schizophrenia Using a Multigene Panel
Objectives. To compare groups of schizophrenia patients with different levels of functional outcomes and different frequencies of risk variants at polymorphic loci of five candidate genes to create a multigene p...
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Article
Investigation of the Relationship between Polymorphism of Human Leukocyte Antigen G (HLA-G) and Social Functioning of Patients with Schizophrenia
Disorders of social functioning are the most persistent consequences of schizophrenia and are an important factor influencing the prognosis of mental disorders. Considering the role of HLA-G in modulating the imm...
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Article
Polygenic Risk Scales for the Development of Depression Using GWAS with Clinical Validation: Methodology and Study Design in the Russian Population
Depression is one of the leading causes of reduced quality of life and social functioning in patients. The prophylaxis of depression is a priority in preventive medicine. Achievement of prophylaxis requires th...
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Article
SLC6A1 and Neuropsychiatric Diseases: The Role of Mutations and Prospects for Treatment with Genome Editing Systems
SLC6A1 (Solute Carrier Family 6 Member 1) is a gene encoding GAT1, the gamma-aminobutyric acid (GABA) transporter protein. GAT1 is responsible for GABA reuptake from the synaptic cleft and intercellular space. Mu...
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Article
Relationship between DNA Methylation within the YJEFN3 Gene and Cognitive Deficit in Schizophrenia Spectrum Disorders
The study investigated methylation of each cytosine within a fragment of the YJEFN3 gene located at one of the index loci of schizophrenia risk with the aim to determine whether methylation of this fragment is as...
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Article
The Effect of INDEL Polymorphism of the Human Leukocyte Antigen G (HLA-G) and the Season of Birth on the Risk of Schizophrenia and Its Clinical Features
By modulating the immunological relationship between the mother and the fetus, as well as interacting with various environmental factors, HLA-G plays an important role in the development of the brain of the em...
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Article
Studies of the Association of Genetic Polymorphism C677T in the Methylenetetrahydrofolate Reductase Gene with Symptom Severity in Schizophrenia Patients
Objective. To study the association of the C677T polymorphism of the MTHFR gene with the risk of develo** schizophrenia in a large cohort including patients with schizophrenia and mentally healthy people and to...
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Article
Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia
The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no diffe...
