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Article
Contemporary Genome-Wide Association Studies in Depression: The Critical Role of Phenoty**
The need to use large cohorts to identify genetic risk loci for mental disorders has led to the dilemma of phenoty** quality. This dilemma is particularly relevant to mental disorders common in the populatio...
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Article
Polygenic Risk Scales for the Development of Depression Using GWAS with Clinical Validation: Methodology and Study Design in the Russian Population
Depression is one of the leading causes of reduced quality of life and social functioning in patients. The prophylaxis of depression is a priority in preventive medicine. Achievement of prophylaxis requires th...
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Article
Open AccessGenome assembly using quantum and quantum-inspired annealing
Recent advances in DNA sequencing open prospects to make whole-genome analysis rapid and reliable, which is promising for various applications including personalized medicine. However, existing techniques for de ...
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Article
Negative Correlation between Natural Human Antibodies Directed to Glycotopes Galβ1-3GlcNAc and Galβ1-4GlcNAc
In a cohort of 106 donors, we analyzed correlations in the binding of natural antibodies to human glycans in a composition of the glycan array. Along with trivial relationships (between structurally similar gl...
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Article
Ultra-Low Coverage Sequencing as the Most Accurate Library Quantification Method Prior to Target Sequencing
Accurate library quantification is very important during post-pooling captured target sequencing. There are a number of methods available to quantify libraries prior to sequencing, but no gold standard for the...
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Article
The increase in aneuploidy of embryos Is associated with pathological morphology of the sperm
Chromosomes of embryos of couples with reduced number of morphologically normal sperm cells (less than 4%) and couples with a normal level of morphologically normal sperm cells (over 4%) has revealed significa...
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Article
Estimation of nonbinary random response
The paper treats a new approach to reducing the dimension of factors which affect the non-binary response variable Y. This is relevant in analysis of a number of stochastic models, for instance, in biological ...
