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Article
Study of the Association between Oxytocin Receptor Gene Polymorphism, Childhood Adversity, and Negative Symptoms of Schizophrenia
It is known that the neurohormone oxytocin plays an important role in the pathogenesis of mental illness and also models the relationship between stress factors, especially those acting in the early stages of ...
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Article
Effects of Oxytocin Pathway Gene Polymorphisms and Adverse Childhood Experiences on the Recognition of Emotion in Schizophrenia Spectrum Disorders
Objectives. To assess the role of interactions between oxytocin pathway gene polymorphisms and adverse childhood experiences (ACE) in deficits of the recognition of emotion in schizophrenia. Materials and methods
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Article
Genetic Polymorphism of Cytokines IL-1β, IL-4, and TNF-α as a Factor Modifying the Influence of Adverse Childhood Experiences on the Symptoms of Schizophrenia
Objectives. Working from the hypothesis that activation of the immune system is one of the mechanisms whereby early environmental factors influence the onset and course of schizophrenia, we studied the effects o...
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Article
The CRP Gene’s Role in the Relations between Childhood Adversity and History of Suicide Attempts in Schizophrenia
Research suggests that, in contrast to circulating C-reactive protein (CRP), genetic variants conferring higher CRP levels have protective effects against schizophrenia and moderate influences of season of bir...
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Article
Prognostication of Functional Outcomes of Schizophrenia Using a Multigene Panel
Objectives. To compare groups of schizophrenia patients with different levels of functional outcomes and different frequencies of risk variants at polymorphic loci of five candidate genes to create a multigene p...
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Article
The Effect of INDEL Polymorphism of the Human Leukocyte Antigen G (HLA-G) and the Season of Birth on the Risk of Schizophrenia and Its Clinical Features
By modulating the immunological relationship between the mother and the fetus, as well as interacting with various environmental factors, HLA-G plays an important role in the development of the brain of the em...
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Article
Studies of the Association of Genetic Polymorphism C677T in the Methylenetetrahydrofolate Reductase Gene with Symptom Severity in Schizophrenia Patients
Objective. To study the association of the C677T polymorphism of the MTHFR gene with the risk of develo** schizophrenia in a large cohort including patients with schizophrenia and mentally healthy people and to...
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Article
Effect of VNTR Polymorphism of the AS3MT Gene and Obstetrical Complications on the Severity of Schizophrenia
The role of the VNTR polymorphism of the AS3MT gene in determining the clinical features of schizophrenia and schizophrenic spectrum disorders was studied. The analysis included 670 individuals. We found no diffe...
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Article
Association of Genes for Proinflammatory Cytokines and Depression
Objectives. To study the association between proinflammatory cytokines and depression. Materials and methods. The: IL-1β C-511T and TNF-α G-308A gene polymorphisms were studied in patients with diagnoses of “depr...
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Article
Effect of the ZNF804A Gene and Obstetrical Complications on Clinical Characteristics of Schizophrenia
To explore for the first time an effect of gene × environment (G × E) interactions on the clinical characteristics of schizophrenia, we studied the ZNF804A rs1344706 polymorphism, a genome-wide supported risk var...
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Article
Studies of the Effects of Genes for Inflammatory Factors on Basic Personality Dimensions
Objective. To study the relationship between the basic personality dimensions and genes encoding various inflammation mediators and biomarkers whose contents are elevated in schizophrenia...
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Article
The Val66Met BDNF Polymorphism Has No Effect on Cognitive Deficit in Schizophrenia Patients or the Risk of This Disease in Their Relatives
Objective. The brain-derived neurotrophic factor gene (BDNF) is a presumptive candidate gene for schizophrenia. Results from many studies have pointed to the absence of any association be...
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Article
M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma
To test the M31R and R335C polymorphisms of the Il8RA gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients ...
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Article
Evenly tritium labeled peptides in study of peptide in vivo and in vitro biodegradation
Biologically active peptides evenly labeled with tritium were used for studying the in vitro and in vivo biodegradation of the peptides. Tritium-labeled peptides with a specific radioactivity of 50–150 Ci/mmol...
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Article
Half-Life of Leu-Enkephalin in the Serum of Infants of the First Year of Life on Different Types of Feeding: Relationship with Temperament
The half-life of leu-enkephalin in the serum of infants aged under 1 year is significantly shorter than in adults. In girls leu-enkephalin half-life is significantly longer than in boys. The half-life of leu-e...
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Article
Effects of Livagen and Epitalon, New Peptide Bioregulators, on Enkephalin-Degrading Enzymes from Human Serum
The effects of new peptide bioregulators—Livagen (Lys-Glu-Asp-Ala) and Epitalon (Ala-Glu-Asp-Gly)—on the endogenous opioid system was studied. In particular, attention was focused on their ability to change th...
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Article
Semax and Selank Inhibit the Enkephalin-Degrading Enzymes of Human Serum
Dose-dependent effect of synthetic heptapeptides Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the enkephalin-degrading enzymes of human serum was demonstrated. The inhibitory...
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Article
The Inhibitory Effect of Selank on Enkephalin-Degrading Enzymes as a Possible Mechanism of Its Anxiolytic Activity
Examination of patients with various forms of anxiety and phobic disorders (according to DSM-4 criteria) demonstrated a considerable shortening of enkephalin half-life and reduced total enkephalinase activity ...
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Article
Relationship between IFN-γ Production by Blood Lymphocytes and Constitutional Personality Features of Patients with Idiopathic Mitral Valve Prolapse
Psychological testing using Eysenck Personality Inventory and immunological testing of 75 patients with idiopathic mitral valve prolapse revealed low production of interferon-γ by blood lymphocytes and a corre...
