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  1. No Access

    Article

    Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

    Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD+ acute myeloid leukaemia (AML). The paucity of valid pre-clinical models has restricted investigations...

    A S Moore, A Faisal, D Gonzalez de Castro, V Bavetsias, C Sun, B Atrash… in Leukemia (2012)

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    Chapter

    γ-Linked Dipeptide Analogues of 2-Desamino-2-Methyl-N10-Propargyl-5,8-Dideazafolate as Antitumour Agents

    Quinazoline analogues of folic acid have been developed successfully as thymidylate synthase (TS) inhibitors which possess clinical activity. CB3717 (N10-propargyl-5,8-dideazafolic acid), the first of these agent...

    A. L. Jackman, G. M. F. Bisset… in Chemistry and Biology of Pteridines and Fo… (1993)