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  1. No Access

    Article

    Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns

    Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD+ acute myeloid leukaemia (AML). The paucity of valid pre-clinical models has restricted investigations...

    A S Moore, A Faisal, D Gonzalez de Castro, V Bavetsias, C Sun, B Atrash… in Leukemia (2012)

  2. No Access

    Article

    Nail biting in rheumatic diseases

    To ascertain if nail biting (usually considered a manifestation of emotional tension) was associated with fibromyalgia, 387 patients attending the Rheumatism Clinic at the Leeds General Infirmary were studied ...

    V. Wright M.D., B. Atrash, R. Hopkins in Clinical Rheumatology (1995)

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    Article

    High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes

    Inhibitors of the conversion of angiotensinogen to the vasoconstrictor angiotensin II have considerable value as antihypertensive agents. For example, captopril and enalapril are clinically useful as inhibitor...

    S. I. Foundling, J. Cooper, F. E. Watson, A. Cleasby, L. H. Pearl, B. L. Sibanda… in Nature (1987)

  4. No Access

    Article

    Potent new inhibitors of human renin

    The renal acid protease renin selectively cleaves its plasma substrate angiotensinogen to release the decapeptide angiotensin I, which in turn is cleaved by a carboxydipeptidase converting enzyme to yield the ...

    M. Szelke, B. Leckie, A. Hallett, D. M. Jones, J. Sueiras, B. Atrash, A. F. Lever in Nature (1982)