23 Result(s)

Article

TCRα rearrangements identify a subgroup of NKL-deregulated adult T-ALLs associated with favorable outcome

T-cell acute lymphoblastic leukemia (T-ALL) results from leukemic transformation of T-cell precursors arrested at specific differentiation stages, including an ‘early-cortical’ thymic maturation arrest charact...

P Villarese, C Lours, A Trinquand, S Le Noir, M Belhocine, L Lhermitte… in Leukemia (2018)

Article

Age-related clinical and biological features of PTEN abnormalities in T-cell acute lymphoblastic leukaemia

The tumour suppressor gene PTEN is commonly altered in T-cell acute lymphoblastic leukaemia but its prognostic impact is still debated. We screened a cohort of 573 fully characterised adult and paediatric T-cell ...

M Tesio, A Trinquand, P Ballerini, G Hypolite, L Lhermitte, A Petit, N Ifrah… in Leukemia (2017)

Article

CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis

G Cordonnier, A Mandoli, A Radhouane, G Hypolite, L Lhermitte, M Belhocine… in Leukemia (2017)

Article

Baboon envelope pseudotyped lentiviral vectors: a highly efficient new tool to genetically manipulate T-cell acute lymphoblastic leukaemia-initiating cells

C Costa, G Hypolite, O Bernadin, C Lévy, F-L Cosset, V Asnafi, E Macintyre… in Leukemia (2017)

Article

Oncogenic PTEN functions and models in T-cell malignancies

PTEN is a protein phosphatase that is crucial to prevent the malignant transformation of T-cells. Although a numerous mechanisms regulate its expression and function, they are often altered in T-cell acute lym...

M Tesio, A Trinquand, E Macintyre, V Asnafi in Oncogene (2016)

Article

Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL

Minimal residual disease (MRD) quantification is widely used for therapeutic stratification in pediatric acute lymphoblastic leukemia (ALL). A robust, reproducible, sensitivity of at least 0.01% has been achie...

R Garand, K Beldjord, H Cavé, C Fossat, I Arnoux, V Asnafi, Y Bertrand… in Leukemia (2013)

Article

Receptor kinase profiles identify a rationale for multitarget kinase inhibition in immature T-ALL

Constitutively activated FLT3 signaling is common in acute myeloid leukemia, and is currently under evaluation for targeted therapy, whereas little data is available in T-cell acute lymphoblastic leukemia (T-A...

L Lhermitte, R Ben Abdelali, P Villarèse, N Bedjaoui, V Guillemot, A Trinquand… in Leukemia (2013)

Article

Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 September 2008

Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the basis of its high prognostic value fo...

M Brüggemann, A Schrauder, T Raff, H Pfeifer, M Dworzak, O G Ottmann, V Asnafi… in Leukemia (2010)

Article

Human erythroleukemia: is the two-hit model of mouse leukemogenesis valid in human disease?

S Coulon, J Vandekerckhove, M Dussiot, C Callens, F Suarez, J Kersual, V Asnafi… in Leukemia (2007)

Article

Most immature T-ALLs express Ra-IL3 (CD123): possible target for DT-IL3 therapy

L Lhermitte, A de Labarthe, C Dupret, H Lapillonne, C Millien, J Landman-Parker… in Leukemia (2006)

Article

HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation

J Bergeron, E Clappier, B Cauwelier, N Dastugue, C Millien, E Delabesse… in Leukemia (2006)

Article

Prediction of relapse by day 100 BCR-ABL quantification after allogeneic stem cell transplantation for chronic myeloid leukemia

Chronic myeloid leukemia (CML) relapse after allogeneic stem cell transplantation (SCT) is a relatively frequent situation, which is correlated to disease status, time from diagnosis to transplant and T-cell d...

V Asnafi, M-T Rubio, E Delabesse, E Villar, F Davi, G Damaj, I Hirsch, N Dhédin… in Leukemia (2006)

Article

IgH/TCR rearrangements are common in MLL translocated adult AML and suggest an early T/myeloid or B/myeloid maturation arrest, which correlates with the MLL partner

C Dupret, V Asnafi, D Leboeuf, C Millien, R Ben Abdelali, C Preudhomme… in Leukemia (2005)

Article

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes

The t(10;11)(p13;q14–21) is found in T-ALL and acute myeloid leukemia and fuses CALM (Clathrin-Assembly protein-like Lymphoid-Myeloid leukaemia gene) to AF10. In order to gain insight into the transcriptional con...

W A Dik, W Brahim, C Braun, V Asnafi, N Dastugue, O A Bernard, J J M van Dongen… in Leukemia (2005)