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  1. Article

    Open Access

    Nuclear localization of beta-catenin involved in precancerous change in oral leukoplakia

    Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expres...

    Kosei Ishida, Satoshi Ito, Naoyuki Wada, Hiroyo Deguchi, Tsuyoshi Hata… in Molecular Cancer (2007)

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    Article

    Immunosuppressant FK506 Induces Neurite Outgrowth in PC12 Mutant Cells with Impaired NGF-Promoted Neuritogenesis via a Novel MAP Kinase Signaling Pathway

    We obtained a drug-hypersensitive PC12 mutant cell (PC12m3), in which neurite outgrowth was strongly stimulated by various drugs such as FK506, calcimycin and cAMP, under the condition of NGF treatment. The fr...

    Yoshio Kano, Tsutomu Nohno, Toru Hasegawa, Rei Takahashi… in Neurochemical Research (2002)

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    Article

    Paraquat-induced gene expression in rat lung tissues using a differential display reverse transcription-polymerase chain reaction

    Increased formation of reactive oxygen species is a cause of paraquat (PQ)-induced injury and also provides a link between the signaling pathways and transcriptional events that regulate the expression of a l...

    Masafumi Tomita, Tsutomu Nohno, Toshiko Okuyama… in Archives of Toxicology (2002)