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Article
Pleiotropy, epistasis and the genetic architecture of quantitative traits
Pleiotropy (whereby one genetic polymorphism affects multiple traits) and epistasis (whereby non-linear interactions between genetic polymorphisms affect the same trait) are fundamental aspects of the genetic ...
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Article
Open AccessPleiotropic fitness effects of the lncRNA Uhg4 in Drosophila melanogaster
Long noncoding RNAs (lncRNAs) are a diverse class of RNAs that are critical for gene regulation, DNA repair, and splicing, and have been implicated in development, stress response, and cancer. However, the fun...
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Article
Open AccessModulation of the Drosophila transcriptome by developmental exposure to alcohol
Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent, preventable pediatric disorder. Identifying genetic risk alleles for FASD is challenging since time, dose, and freque...
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Article
Open AccessIbrutinib as a potential therapeutic for cocaine use disorder
Cocaine use presents a worldwide public health problem with high socioeconomic cost. No current pharmacologic treatments are available for cocaine use disorder (CUD) or cocaine toxicity. To explore pharmaceuti...
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Article
Open AccessGenotype by environment interaction for gene expression in Drosophila melanogaster
The genetics of phenotypic responses to changing environments remains elusive. Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in ...
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Article
Open AccessTesting the assumptions of parametric linear models: the need for biological data mining in disciplines such as human genetics
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Article
Open AccessGenome-Wide Association Study of Circadian Behavior in Drosophila melanogaster
Circadian rhythms influence physiological processes from sleep–wake cycles to body temperature and are controlled by highly conserved cycling molecules. Although the mechanistic basis of the circadian clock ha...
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Article
Open AccessEffect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals
Predicting complex phenotypes from genomic data is a fundamental aim of animal and plant breeding, where we wish to predict genetic merits of selection candidates; and of human genetics, where we wish to predi...
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Article
The road less traveled: from genotype to phenotype in flies and humans
Understanding how genomic variation gives rise to phenotypic variation is essential for elucidating mechanisms of adaptive evolution, plant and animal breeding, and precision medicine. However, identifying cau...
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Article
Open AccessRegulation of Drosophila Lifespan by bellwether Promoter Alleles
Longevity varies among individuals, but how natural genetic variation contributes to variation in lifespan is poorly understood. Drosophila melanogaster presents an advantageous model system to explore the geneti...
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Article
Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster
Food consumption is an essential component of animal fitness; however, excessive food intake in humans increases risk for many diseases. The roles of neuroendocrine feedback loops, food sensing modalities, and...
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Article
Evaluation of artificial selection in Standard Poodles using whole-genome sequencing
Identifying regions of artificial selection within dog breeds may provide insights into genetic variation that underlies breed-specific traits or diseases—particularly if these traits or disease predisposition...
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Article
Open AccessThe genetic basis of natural variation in mushroom body size in Drosophila melanogaster
Genetic variation in brain size may provide the basis for the evolution of the brain and complex behaviours. The genetic substrate and the selective pressures acting on brain size are poorly understood. Here w...
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Article
Open AccessPolymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila
Alcohol abuse and alcoholism are significant public health problems, but the genetic basis for individual variation in alcohol sensitivity remains poorly understood. Drosophila melanogaster presents a powerful mo...
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Article
Open AccessGenetic map** uncovers cis-regulatory landscape of RNA editing
Adenosine-to-inosine (A-to-I) RNA editing, catalysed by ADAR enzymes conserved in metazoans, plays an important role in neurological functions. Although the fine-tuning mechanism provided by A-to-I RNA editing...
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Article
Open AccessErratum to: Why epistasis is important for tackling complex human disease genetics
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Article
Open AccessGenetic Architecture of Micro-Environmental Plasticity in Drosophila melanogaster
Individuals of the same genotype do not have the same phenotype for quantitative traits when reared under common macro-environmental conditions, a phenomenon called micro-environmental plasticity. Genetic vari...
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Epistasis for Quantitative Traits in Drosophila
The role of gene–gene interactions in the genetic architecture of quantitative traits is controversial, despite the biological plausibility of nonlinear molecular interactions underpinning variation in quantit...
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Article
Does evolutionary theory need a rethink?
Researchers are divided over what processes should be considered fundamental.
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Article
Open AccessGenetics and genomics of alcohol sensitivity
Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among...
