47 Result(s)

Article

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

Article

The future of model organisms in human disease research

The genetic architecture of human disease is often hard to replicate in model organisms, and disease modelling in human cells is rapidly improving. Six leading model organism researchers provide their perspect...

Timothy J. Aitman, Charles Boone, Gary A. Churchill… in Nature Reviews Genetics (2011)

Article

Finding the missing heritability of complex diseases

Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases, but most confer quite small increments of risk. There seems to be a large component of herit...

Teri A. Manolio, Francis S. Collins, Nancy J. Cox, David B. Goldstein… in Nature (2009)

Article

The genetics of quantitative traits: challenges and prospects

Article

The genetic architecture of complex behaviors: lessons from Drosophila

Complex behaviors are affected by multiple interacting loci with individually small and environmentally sensitive effects. Understanding the genetic architecture of behavioral traits begins with identifying th...

Trudy F. C. Mackay in Genetica (2009)

Article

Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep

Trudy Mackay and colleagues measure sleep phenotypes in 40 wild-derived Drosophila lines, and report candidate genes and transcriptional networks associated with sleep regulation.

Susan T Harbison, Mary Anna Carbone, Julien F Ayroles, Eric A Stone… in Nature Genetics (2009)

Article

Systems genetics of complex traits in Drosophila melanogaster

Trudy Mackay and colleagues present a resource of 40 Drosophila melanogaster wild-derived inbred lines. The authors quantify genome-wide variation in transcript abundance for six ecologically relevant traits, cha...

Julien F Ayroles, Mary Anna Carbone, Eric A Stone, Katherine W Jordan… in Nature Genetics (2009)

Article

Speed-map** quantitative trait loci using microarrays

We developed a rapid, economical method for high-resolution quantitative trait locus (QTL) map** using microarrays for selective genoty** of pooled DNA samples. We generated 21,207 F₂ flies from two inbred Dr...

Chao-Qiang Lai, Jeff Leips, Wei Zou, Jessica F Roberts, Kurt R Wollenberg… in Nature Methods (2007)

Article

Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster

The abundance of transposable elements and DNA repeat sequences in mammalian genomes raises the question of whether such insertions represent passive evolutionary baggage or may influence the expression of com...

Stephanie M Rollmann, Michael M Magwire, Theodore J Morgan, Ergi D Özsoy… in Nature Genetics (2006)

Article

Microclinal variation for ovariole number and body size in Drosophila melanogaster in ‘Evolution Canyon’

Sites that display strong environmental contrasts in close proximity, such as ‘Evolution Canyon’ on Mt. Carmel, Israel, are natural theatres for investigating adaptive evolution in action. We reared Drosophila me...

Marta L. Wayne, Abraham Korol, Trudy F. C. Mackay in Genetica (2005)

Article

Complementing complexity

One challenge in modern biology is to understand the detailed genetic basis of variation for quantitative traits, including complex behaviors. A new study shows that historical recombination in outbred strains...

Trudy F C Mackay in Nature Genetics (2004)

Article

Quantitative genetic analyses of complex behaviours in Drosophila

Article

The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome

We combined transcriptional profiling and quantitative genetic analysis to elucidate the genetic architecture of olfactory behavior in Drosophila melanogaster. We applied whole-genome expression analysis to five ...

Robert R H Anholt, Christy L Dilda, Sherman Chang, Juan-José Fanara… in Nature Genetics (2003)

Article

Dopa decarboxylase (Ddc) affects variation in Drosophila longevity

Mutational analyses in model organisms have shown that genes affecting metabolism and stress resistance regulate life span¹, but the genes responsible for variation in longevity in natural populations are largely...

Maria De Luca, Nataliya V Roshina, Gretchen L Geiger-Thornsberry… in Nature Genetics (2003)

Article

Quantitative trait loci in Drosophila

Article

The Genetic Architecture of Odor-Guided Behavior in Drosophila melanogaster

The avoidance response to repellent odorants in Drosophila melanogaster, a response essential for survival, provides an advantageous model for studies on the genetic architecture of behavior. Transposon tagging i...

Robert R. H. Anholt, Trudy F. C. Mackay in Behavior Genetics (2001)

Article

Polygenic mutation in Drosophila melanogaster: genotype × environment interaction for spontaneous mutations affecting bristle number

A highly inbred line of Drosophila melanogaster was subdivided into replicate sublines that were subsequently maintained independently with 10 pairs of parents per generation. The parents were randomly sampled...

Trudy F.C. Mackay, Richard F. Lyman in Genetica (1998)

Chapter

Polygenic mutation in Drosophila melanogaster: genotype × environment interaction for spontaneous mutations affecting bristle number

A highly inbred line of Drosophila melanogaster was subdivided into replicate sublines that were subsequently maintained independently with 10 pairs of parents per generation. The parents were randomly sampled fo...

Trudy F. C. Mackay, Richard F. Lyman in Mutation and Evolution (1998)