32 Result(s)

Chapter and Conference Paper

Measurements of Acoustic Emission and Deformation in a Repository of Nuclear Waste in Salt Rock

Measurements of acoustic emission have been performed since 1994 in a repository of nuclear waste (a former salt mine) in combination with deformation measurements in order to monitor the mine structure regard...

Jürgen Hesser, Diethelm Kaiser… in Engineering Geology for Society and Territ… (2015)

Article

Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding

MICA is a ligand of the activating receptor NKG2D, expressed by NK and T cells. MICA expression is induced in cancer cells favoring their elimination by the immune system; however, many advanced tumors shed so...

Leticia Huergo-Zapico, Ana P. Gonzalez-Rodriguez… in Cancer Immunology, Immunotherapy (2012)

Article

Regulation of NKG2D ligands: a purposeful but delicate affair

New findings show that cellular microRNAs 'calibrate' the baseline expression of mRNAs encoding stress-inducible ligands of the activating NKG2D receptor. This regulation serves to protect innocent cells but m...

Thomas Spies in Nature Immunology (2008)

Article

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

A number of advanced tumours appear to evade immune recognition by natural killer cells by shedding the soluble major histocompatibility complex class I-related ligand MICA, which inactivates the NKG2D recepto...

Brett K. Kaiser, Daesong Yim, I-Ting Chow, Segundo Gonzalez, Zhenpeng Dai… in Nature (2007)

Article

Fas ligand–mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity

Tumor-associated ligands of the activating NKG2D receptor can effectively stimulate T cell responses at early but not late stages of tumor growth. In late-stage human tumor settings, we observed MIC-driven pro...

Veronika Groh, Kimberly Smythe, Zhenpeng Dai, Thomas Spies in Nature Immunology (2006)

Article

Natural cytotoxicity receptors: influenza virus in the spotlight

NKp46, an activating receptor expressed on natural killer cells, protects from lethal influenza virus infection. Contrary to prevailing views, involvement of NKp46 in tumor immunity is uncertain.

Thomas Spies, Veronika Groh in Nature Immunology (2006)

Article

Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease

The NKG2D receptor costimulates effector/memory CD8 T cells and is normally absent on CD4 T cells but can be induced by T cell antigen receptor complex stimulation and interleukin-15 (IL-15). Among its ligands...

Nazli Azimi, Steven Jacobson, Yuetsu Tanaka, Lawrence Corey… in Immunogenetics (2006)

Article

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation

Engagement of the NKG2D receptor by tumour-associated ligands may promote tumour rejection by stimulating innate and adaptive lymphocyte responses^1,2,3,4,5. In humans, NKG2D is expressed on most natural killer ce...

Veronika Groh, Jennifer Wu, Cassian Yee, Thomas Spies in Nature (2002)

Article

Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA

The major histocompatibility complex (MHC) class I homolog, MICA, is a stress-inducible ligand for NKG2D, a C-type lectin–like activating immunoreceptor. The crystal structure of this ligand-receptor complex t...

**wei Li, Daniel L. Morris, Benjamin E. Willcox, Alexander Steinle… in Nature Immunology (2001)

Article

Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family

NKG2D is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells. Among its ligands is the distant major histocompatibility complex class I homolog MICA, whi...

Alexander Steinle, **wei Li, Daniel L. Morris, Veronika Groh… in Immunogenetics (2001)

Article

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

NKG2D is an activating receptor that stimulates innate immune responses by natural killer cells upon engagement by MIC ligands, which are induced by cellular stress. Because NKG2D is also present on most CD8αβ...

Veronika Groh, Rebecca Rhinehart, Julie Randolph-Habecker, Max S. Topp… in Nature Immunology (2001)

Article

Population study of allelic diversity in the human MHC class I-related MIC-A gene

 The polymorphism of major histocompatibility complex (MHC) class I HLA-A, -B, and -C molecules may have evolved through pathogen-driven selection of alleles with diverse peptide-binding specificities. Two MHC...

E. W. Petersdorf, Klaus B. Shuler, Gary M. Longton, Thomas Spies… in Immunogenetics (1999)

Article

Allelic repertoire of the humanMHC class IMICA gene

The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassicalMHC class I genes. A distinct fami...

Nassima Fodil, Laurent Laloux, Valérie Wanner, Philippe Pellet… in Immunogenetics (1996)

Article

Nucleotide sequence of a human MHC class IMICB cDNA

Seiamak Bahram, Thomas Spies in Immunogenetics (1996)

Article

Nucleotide sequence of the humanMHC class IMICA gene

Seiamak Bahram, Nobuhisa Mizuki, Hidetoshi Inoko, Thomas Spies in Immunogenetics (1996)