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Article
Open AccessKetogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity
Growing evidence supports the use of low-carbohydrate/high-fat ketogenic diets as an adjunctive cancer therapy. However, it is unclear which genetic, metabolic, or immunological factors contribute to the benef...
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Article
Open AccessManagement of intoxicated patients – a descriptive outcome analysis of 4,267 ICU patients
Intoxications are common in intensive care units (ICUs). The number of causative substances is large, mortality usually low. This retrospective cohort study aims to characterize differences of intoxicated comp...
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Article
Open AccessSoluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
Prognostication after cardiopulmonary resuscitation (CPR) is complex. Novel biomarkers like soluble suppression of tumorigenicity 2 (sST2) may provide an objective approach. A total of 106 post-CPR patients we...
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Article
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
Microglia become progressively activated and seemingly dysfunctional with age, and genetic studies have linked these cells to the pathogenesis of a growing number of neurodegenerative diseases. Here we report ...
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Article
Open AccessBasal pharmacokinetic parameters of topically applied diacerein in pediatric patients with generalized severe epidermolysis bullosa simplex
Generalized severe epidermolysis bullosa simplex (EBS-gen sev) is caused by mutations within either the KRT5 or KRT14 gene, phenotypically resulting in blistering and wounding of the skin and mucous membranes aft...
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Article
Open AccessTopical diacerein for epidermolysis bullosa: a randomized controlled pilot study
Blistering in epidermolysis bullosa simplex type Dowling-Meara (EBS-DM) is associated with an inflammatory phenotype, which can be disrupted by diacerein in vitro. In this pilot study we hypothesized, that a topi...
