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Article
Application of a mechanism-based disease systems model for osteoporosis to clinical data
A recently proposed mechanism-based disease systems model for osteoporosis (Schmidt et al., J Pharmacokinet Pharmacodyn 38:873–900, 2011) was applied to clinical data from post-menopausal women (n = 767) receivin...
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Article
Open AccessCo** with time scales in disease systems analysis: application to bone remodeling
In this study we demonstrate the added value of mathematical model reduction for characterizing complex dynamic systems using bone remodeling as an example. We show that for the given parameter values, the mec...
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Chapter
Disease Progression Analysis: Towards Mechanism-Based Models
Sustained disturbances of the biological homeostasis can result in chronic progressive diseases. The respective disease status as well as the corresponding effect of drug treatment on disease progression can b...
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Article
Bone Physiology, Disease and Treatment
Osteoporosis is a chronic progressive disorder and is regarded as an important worldwide health issue. The development of novel treatments and the comparison of the effects of novel and existing treatments in ...
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Article
Open AccessExtensions to the Visual Predictive Check to facilitate model performance evaluation
The Visual Predictive Check (VPC) is a valuable and supportive instrument for evaluating model performance. However in its most commonly applied form, the method largely depends on a subjective comparison of t...
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Article
Open AccessApplication of the Convection–Dispersion Equation to Modelling Oral Drug Absorption
Models of systemic drug absorption after oral administration are frequently based on a direct or a delayed first-order rate process. In practice, the use of the first-order approach to predict drug concentrati...
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Article
Disease System Analysis: Basic Disease Progression Models in Degenerative Disease
To describe the disease status of degenerative diseases (i.e., type 2 diabetes mellitus, Parkinson’s disease) as function of disease process and treatment effects, a family of disease progression models is int...
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Article
Pharmacotherapy of Hospitalised HIV-Infected Patients in a General Hospital during 1990, 1997 and 2001
To describe the changes over time in drug therapy (antiretroviral as well as co-administered drugs) in HIV-infected patients who required hospitalisation during the period 1990–2001. In addition, we wanted to ...
