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Open AccessClinical Pharmacokinetics and Pharmacodynamics of the Selective Progesterone Receptor Modulator Vilaprisan: A Comprehensive Overview
Vilaprisan is a highly potent selective progesterone receptor modulator in development for the treatment of symptomatic uterine fibroids and endometriosis. Its pharmacokinetics are characterized by rapid absor...
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Pharmacokinetic–Pharmacodynamic Modeling of the Antihypertensive Effect of Eprosartan in Black and White Hypertensive Patients
It is well recognized that many antihypertensive drugs exhibit large interindividual variability in effect and that this wide range of patient response to antihypertensive drugs is a major problem in achieving...
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Mechanism-based PK–PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans
The aim of this investigation was to develop a mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) model for the biological system prolactin response following a dopamine inhibition challenge using remoxip...
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Open AccessMarginal increase of sunitinib exposure by grapefruit juice
The drug label of sunitinib includes a warning for concomitant use of grapefruit juice (GJ) but clinical evidence for this drug interaction is lacking. The aim of this study is to determine the effect of GJ, a...
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Disease Progression Analysis: Towards Mechanism-Based Models
Sustained disturbances of the biological homeostasis can result in chronic progressive diseases. The respective disease status as well as the corresponding effect of drug treatment on disease progression can b...
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Open AccessExplaining variability in ciclosporin exposure in adult kidney transplant recipients
Optimal ciclosporin A (CsA) exposure in kidney transplant recipients is difficult to attain because of variability in CsA pharmacokinetics. A better understanding of the variability in CsA exposure could be a ...
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Open AccessExtensions to the Visual Predictive Check to facilitate model performance evaluation
The Visual Predictive Check (VPC) is a valuable and supportive instrument for evaluating model performance. However in its most commonly applied form, the method largely depends on a subjective comparison of t...
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Article
Open AccessApplication of the Convection–Dispersion Equation to Modelling Oral Drug Absorption
Models of systemic drug absorption after oral administration are frequently based on a direct or a delayed first-order rate process. In practice, the use of the first-order approach to predict drug concentrati...
