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  1. Article

    Open Access

    How autoreactive thymocytes differentiate into regulatory versus effector CD4+ T cells after avoiding clonal deletion

    Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to differentiate into specialized regulatory T (Treg) or effector ...

    Xuguang Tai, Alyssa Indart, Mirelle Rojano, Jie Guo, Nicolai Apenes… in Nature Immunology (2023)

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  2. Article

    Open Access

    Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus

    T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains un...

    Miho Shinzawa, E. Ashley Moseman, Selamawit Gossa, Yasuko Mano… in Nature Immunology (2022)

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  3. No Access

    Article

    Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

    Whether CD8-lineage specification and CD8+ T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that interleukin 7 specifies CD8-lineage choice and promote...

    Jung-Hyun Park, Stanley Adoro, Terry Guinter, Batu Erman, Amala S Alag… in Nature Immunology (2010)