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Article
Open AccessNecroptosis stimulates interferon-mediated protective anti-tumor immunity
Necroptosis is an inflammatory form of cell suicide that critically depends on the kinase activity of Receptor Interacting Protein Kinase 3 (RIPK3). Previous studies showed that immunization with necroptotic c...
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Article
Olfactory immunology: the missing piece in airway and CNS defence
The olfactory mucosa is a component of the nasal airway that mediates the sense of smell. Recent studies point to an important role for the olfactory mucosa as a barrier to both respiratory pathogens and to ne...
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Article
Open AccessOlfactory immune response to SARS-CoV-2
Numerous pathogens can infect the olfactory tract, yet the pandemic caused by SARS-CoV-2 has strongly emphasized the importance of the olfactory mucosa as an immune barrier. Situated in the nasal passages, the...
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Protocol
Identification of Immune Cells in Murine Olfactory Mucosa
Olfactory immunology is an emerging field in the context of infectious disease and neuroimmunology, yet characterization of immune cells within the murine olfactory mucosa remains sparse. This is partially due...
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Article
Open AccessReversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains un...
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Article
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
A Correction to this paper has been published: https://doi.org/10.1038/s41590-021-00906-4.
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Article
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
During chronic infection and cancer, a self-renewing CD8+ T cell subset maintains long-term immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8+ T cells diverge from other CD8+ sub...
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Article
Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection
Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share transcriptional regulators with memory precursor cells...
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Article
Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses
NK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory that is protective against various viruses.
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Article
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus
Microorganisms that breach the body's external defences and enter the lymphatic system are liable to be captured by the lymph nodes, and recent work showed that a subset of macrophages found in the subcapsular...
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Article
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Lymph nodes help clear infecting pathogens and prevent their dissemination. In the case of lymph-borne virus, this involves a particular subpopulation of macrophages that is shown to capture the viral particle...
