-
Article
Evaluation of Clinical and Immunological Alterations Associated with ICF Syndrome
Immunodeficiency with centromeric instability and facial anomalies (ICF) syndrome is a rare autosomal recessive combined immunodeficiency. The detailed immune responses are not explored widely. We investigated...
-
Article
Open AccessExpression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system
The interleukin-1 receptor antagonist (IL-1Ra) is a crucial molecule that counteracts the effects of interleukin-1 (IL-1) by binding to its receptor. A high concentration of IL-1Ra is required for complete inh...
-
Article
Open AccessReversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR signals generate CD8 cytotoxic T cells, but the basis remains un...
-
Article
Open AccessThe fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma
Glioblastoma Multiforme (GBM) is the most common and aggressive primary brain tumor. Despite recent developments in surgery, chemo- and radio-therapy, a currently poor prognosis of GBM patients highlights an u...
-
Article
Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus
T cells develo** in the thymus are signaled during positive selection to differentiate into either CD4+ T cells or CD8+ T cells. Singer and colleagues show that CD8+-lineage specification is signaled exclusivel...
-
Article
Long noncoding RNA (lincRNA), a new paradigm in gene expression control
Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer than 200 nucleotides. By definition, these RNAs must not have open reading frames that encode proteins. Many of these t...
-
Article
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Whether CD8-lineage specification and CD8+ T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that interleukin 7 specifies CD8-lineage choice and promote...
-
Article
Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
Compared with naive CD8+ T cells, naive CD4+ T cells undergo inefficient homeostatic proliferation. Mackall and colleagues now attribute this difference to interleukin 7–mediated suppression of the expression of ...
-
Article
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we ...
-
Article
Early TCRα expression generates TCRαγ complexes that signal the DN-to-DP transition and impair development
Clonotypic T cell receptor (TCR) genes undergo ordered rearrangement and expression in the thymus with the result that TCRα and TCRγ proteins are not expressed in the same cell at the same time. Such “TCRα/γ e...
