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    Article

    Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

    Cyclophilin A binds a proline motif in human CrkII, preventing phosphorylation by Abl and EGFR. Decreased CrkII phosphorylation ensures interactions with the focal adhesion proteins paxillin and p130CAS to sti...

    Tamjeed Saleh, Wojciech Jankowski, Ganapathy Sriram, Paolo Rossi… in Nature Chemical Biology (2016)

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    Article

    Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII

    NMR structures of CrkL, an adaptor protein that mediates Bcr-Abl signaling in CML, reveal domain organization distinct from CrkII that allows constitutive interaction between CrkL and Abl kinase.

    Wojciech Jankowski, Tamjeed Saleh, Ming-Tao Pai… in Nature Chemical Biology (2012)

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    Article

    Structural basis for regulation of the Crk signaling protein by a proline switch

    Structural analysis by NMR reveals that the Gly237-Pro238 bond of the signaling protein Crk in the cis form stabilizes an autoinhibited conformation between two tandem SH3 domains, whereas the trans form promotes...

    Paramita Sarkar, Tamjeed Saleh, Shiou-Ru Tzeng, Raymond B Birge… in Nature Chemical Biology (2011)