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Article
Recent advancements in cartilage tissue engineering innovation and translation
Articular cartilage was expected to be one of the first successfully engineered tissues, but today, cartilage repair products are few and they exhibit considerable limitations. For example, of the cell-based p...
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Article
Commercialization of regenerative-medicine therapies
The clinical translation of regenerative-medicine products, including cell therapies, therapeutic tissue engineering products, and human cell and tissue products, remains limited because of the so-called ‘vall...
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Article
Eu(III) transfer in single N,N,N’,N’-tetraoctyldiglycolamide-impregnated polymer-coated silica particle using fluorescence microspectroscopy: transfer mechanism and effect of polymer crosslinking degree
A microcapillary manipulation system combined with fluorescence microspectroscopy enabled us to analyze mass transfer in a single particle. In this study, we revealed the Eu(III) distribution in a single digly...
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Article
Open AccessPolydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis
Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of autologous chondrocyte cell-sheets along with open-wedge high tibial...
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Article
Open AccessComparison of properties determined using electromechanical assessment (Arthro-BST™) with macroscopic and histological properties in symptomatic human articular cartilage of the hip
Cartilage degeneration is assessed using various methods. Although macroscopic evaluation can directly measure cartilage degeneration, it cannot accurately assess cartilage properties. Histological examination...
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Article
Chemokine ligand 28 (CCL28) negatively regulates trabecular bone mass by suppressing osteoblast and osteoclast activities
Bone metabolism imbalances cause bone metabolism diseases, like osteoporosis, through aging. Although some chemokines are known to be involved in bone mass regulation, many have not been investigated. Thus, th...
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Chapter and Conference Paper
Multi-span Extractive Reading Comprehension Without Multi-span Supervision
This study focuses on multi-span reading comprehension (RC), which requires answering questions with multiple text spans. Existing approaches for extracting multiple answers require an elaborate dataset that c...
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Article
Open AccessCharacteristics of autologous protein solution and leucocyte-poor platelet-rich plasma for the treatment of osteoarthritis of the knee
Recently, platelet-rich plasma (PRP) has received attention as a treatment for patients with osteoarthritis of the knee (OAK), a chronic degenerative disease, to bridge the gap between conservative and surgica...
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Article
Open AccessCharacterization of polydactyly-derived chondrocyte sheets versus adult chondrocyte sheets for articular cartilage repair
We previously conducted a first-in-human clinical study of articular cartilage repair using autologous chondrocyte sheets and confirmed the regeneration of hyaline-like cartilage in all eight patients. However...
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Chapter
A Challenging Synthesis of the Highly Functionalized Echinocandin ASP9726: A Successor of Micafungin—How Can We Achieve the Large-Scale Synthesis?
Here, we describe a challenging scale-up synthesis of the highly functionalized echinocandin ASP9726 (1) starting from the natural product FR901379 (3), the same raw material of micafungin (2). The synthesis dema...
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Chapter
Natural Language Dialog System Considering Speaker’s Emotion Calculated from Acoustic Features
With the of Interactive Voice Response (IVR) , can not only computer systems through task-oriented but also enjoy non-task-oriented conversation with the computer. When an IVR system generates a respo...
