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  1. Article

    Open Access

    Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation

    Brain inflammation generally accompanies and accelerates neurodegeneration. Here we report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses extrinsic tau 3R/4R proteins by direct ...

    Meihua **, Hiroki Shiwaku, Hikari Tanaka, Takayuki Obita… in Nature Communications (2021)

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  2. No Access

    Protocol

    Crystallization and Biophysical Approaches for Studying the Interactions Between the Vps4-MIT Domain and ESCRT-III Proteins

    The AAA ATPase Vps4 disassembles the ESCRT complex from the endosomal membrane. Vps4 contains an N-terminal MIT (microtubule interacting and transport) domain and a C-terminal catalytic domain. The MIT domain ...

    Takayuki Obita, Rieko Kojima, Mineyuki Mizuguchi in The ESCRT Complexes (2019)

  3. Article

    Open Access

    Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1

    The megakaryoblastic leukemia 1 (MKL1) protein functions as a transcriptional coactivator of the serum response factor. MKL1 has three RPEL motifs (RPEL1, RPEL2 and RPEL3) in its N-terminal region. MKL1 binds ...

    Mineyuki Mizuguchi, Takahiro Fuju, Takayuki Obita, Mitsuru Ishikawa… in Scientific Reports (2014)

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  4. No Access

    Article

    Mutations in the PQBP1 gene prevent its interaction with the spliceosomal protein U5–15kD

    A loss-of-function of polyglutamine tract-binding protein 1 (PQBP1) induced by frameshift mutations is believed to cause X-linked mental retardation. However, the mechanism by which structural changes in PQBP1...

    Mineyuki Mizuguchi, Takayuki Obita, Tomohito Serita, Rieko Kojima… in Nature Communications (2014)

  5. No Access

    Article

    Structural basis for selective recognition of ESCRT-III by the AAA ATPase Vps4

    In yeast, two ESCRT-III-related subunits, Vps2 and Did2 bind to Vps4. The crystal structure of Vps2 bound to Vp4 s is presented, elucidating the basis for selective recognition of the ESCRT-III complex.

    Takayuki Obita, Suraj Saksena, Sara Ghazi-Tabatabai, David J. Gill, Olga Perisic… in Nature (2007)

  6. No Access

    Article

    Letter to the Editor: Assignment of 1H and 15N resonances of mouse lysozyme M

    Takayuki Obita, Tadashi Ueda, Yoshitsugu Tanaka… in Journal of Biomolecular NMR (2000)