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Open AccessMechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targets for molecular therapy. However, there remain cases where target genes are not identi...
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Article
Open AccessExercise pulmonary hypertension in patients with systemic sclerosis based on updated guidelines
Recent European guidelines have introduced the concept of exercise pulmonary hypertension (ex-PH). However, the clinical characteristics of ex-PH in systemic sclerosis (SSc) remains unknown. We aimed to invest...
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Article
Open AccessGenomic profiles of Japanese patients with vulvar squamous cell carcinoma
The incidence of vulvar carcinoma varies by race; however, it is a rare disease, and its genomic profiles remain largely unknown. This study examined the characteristics of vulvar squamous cell carcinoma (VSCC...
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Article
Open AccessAge at lung cancer diagnosis in females versus males who never smoke by race and ethnicity
We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.
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Article
Open AccessAdvances in cancer DNA methylation analysis with methPLIER: use of non-negative matrix factorization and knowledge-based constraints to enhance biological interpretability
DNA methylation is an epigenetic modification that results in dynamic changes during ontogenesis and cell differentiation. DNA methylation patterns regulate gene expression and have been widely researched. Whi...
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Article
Open AccessWhole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma
The mechanism underlying the development of tumors, particularly at early stages, still remains mostly elusive. Here, we report whole-genome long and short read sequencing analysis of 76 lung cancers, focusing...
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Sex differences in insomnia, sleep apnea and restless legs syndrome—reply -
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Article
Correction: Tumor microenvironment-mediated immune profiles and efficacy of anti-PD-L1 antibody plus chemotherapy stratified by DLL3 expression in small-cell lung cancer
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Open AccessAn ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
Activation of the KRAS oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we show that induction of KRASG12V expres...
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Article
Open AccessContribution of an Asian-prevalent HLA haplotype to the risk of HBV-related hepatocellular carcinoma
Liver cancer, particularly hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), is more common in Asians than in Caucasians. This is due, at least in part, to regional differences in the prevalence ...
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Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Open AccessInhibition of the mitochondria-sha** protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinomaresistant cell line
Drug resistance limits the efficacy of chemotherapy and targeted cancer treatments, calling for the identification of druggable targets to overcome it. Here we show that the mitochondria-sha** protein Opa1 p...
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Article
Open AccessUtility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer
We investigated the utility of a molecular classifier tool and genetic alterations for predicting prognosis in Japanese patients with endometrial cancer.
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Open AccessComparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts
Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare the genetic backgrounds and their effect on clinical outcomes between Japanese and Caucasian patients with...
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Article
Open AccessPredictive model for the preoperative assessment and prognostic modeling of lymph node metastasis in endometrial cancer
Lymph node metastasis (LNM) is a well-established prognostic factor in endometrial cancer (EC). We aimed to construct a model that predicts LNM and prognosis using preoperative factors such as myometrial invas...
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Article
Open AccessAssociation between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction
We clarified the association between changes in the number of foundational medications for heart failure (FMHF) during hospitalization for worsening heart failure (HF) and post-discharge prognosis. We retrospe...
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Open AccessPhasing analysis of lung cancer genomes using a long read sequencer
Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct the phasing analysis of non-small cell lung cancer specimens of 20 Japanese patients. By the combinatory use of short and l...
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Article
Open AccessPotential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction
Malnutrition is common in patients with heart failure with reduced ejection fraction (HFrEF) and may influence the long-term prognosis and allocation of combination medical therapy. We reviewed 1231 consecutiv...
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Article
Open AccessHigh prevalence of occult left ventricular diastolic dysfunction detected by exercise stress test in systemic sclerosis
Despite the poor prognosis of systemic sclerosis (SSc) due to the co-occurrence of left ventricular diastolic dysfunction (LVDD), presence of occult LVDD has not been sufficiently investigated. This retrospect...
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Article
Open AccessScaling advantage of chaotic amplitude control for high-performance combinatorial optimization
The development of physical simulators, called Ising machines, that sample from low energy states of the Ising Hamiltonian has the potential to transform our ability to understand and control complex systems. ...
