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Article
Third Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on diabetes and cancer: summary of the results of a questionnaire survey of oncologists and diabetologists—secondary publication
The Japan Diabetes Society (JDS) and the Japan Cancer Association (JCA) launched a joint committee and published their “First Joint Committee Report on Diabetes and Cancer” in 2013, compiling recommendations f...
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Article
Open AccessEast Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease
Peptic ulcer disease (PUD) refers to acid-induced injury of the digestive tract, occurring mainly in the stomach (gastric ulcer (GU)) or duodenum (duodenal ulcer (DU)). In the present study, we conducted a lar...
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Article
Open AccessContribution of an Asian-prevalent HLA haplotype to the risk of HBV-related hepatocellular carcinoma
Liver cancer, particularly hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), is more common in Asians than in Caucasians. This is due, at least in part, to regional differences in the prevalence ...
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Article
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
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Article
Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Article
Open AccessGenome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals
Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the r...
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Article
Open AccessCross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction
Atrial fibrillation (AF) is a common cardiac arrhythmia resulting in increased risk of stroke. Despite highly heritable etiology, our understanding of the genetic architecture of AF remains incomplete. Here we...
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Article
Open AccessIdentification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes
Type 2 diabetes is a common disease around the world and its major complications are diabetic retinopathy (DR) and diabetic kidney disease (DKD). Persons with type 2 diabetes with complications, especially who...
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Article
Open AccessImplicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understandi...
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Article
Influence of microbubbles on free radical generation by ultrasound in aqueous solution: implication of the important roles of nanobubbles
Although research on microbubbles (MBs) has intrigued a lot of researchers, very few studies have been done about the influences of MBs on the free radical formation and also on the degradation rates of organi...
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Article
Open AccessUsefulness of circulating tumor DNA by targeting human papilloma virus-derived sequences as a biomarker in p16-positive oropharyngeal cancer
In head and neck cancer, early detection of recurrence after treatment is important. The contemporary development of therapeutic agents have improved the prognosis after recurrence; however, no biomarker has b...
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Chapter
Defect Engineering Using the High-Energy Laser-Processing Techniques and Their Application to Photocatalysis
Laser processing to the photocatalytic powders in water was performed for the BiVO4-based photocatalyst as well as metal oxide photocatalyst. For BiZn2VO6 and BiCu2VO6 photocatalysts, photocurrent enhancement was...
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Article
The power of genetic diversity in genome-wide association studies of lipids
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treat...
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Article
Open AccessPharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches. Here, we ...
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Article
A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 ...
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Article
Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleo...
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Chapter and Conference Paper
Mathematical Modeling of the Dimerization of EGFR and ErbB3 in Lung Adenocarcinoma
The most common driver mutations in lung adenocarcinoma occur in the EGFR gene. Gefitinib, an EGFR tyrosine kinase inhibitor, is an effective therapy for lung adenocarcinoma with EGFR mutations. However, resistan...
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Article
Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements
Poor trans-ancestry portability of polygenic risk scores is a consequence of Eurocentric genetic studies and limited knowledge of shared causal variants. Leveraging regulatory annotations may improve portabili...
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Article
Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease
To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we conducted a large-scale genome-wide association study of 168,228 individuals of Japanese ancestry (25,892 cases and 142...
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Article
Open AccessMint3 depletion restricts tumor malignancy of pancreatic cancer cells by decreasing SKP2 expression via HIF-1
Pancreatic cancer is one of the most fatal cancers without druggable molecular targets. Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcriptional factor that promotes malignancy in various cancers ...
