25 Result(s)
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Open AccessExercise pulmonary hypertension in patients with systemic sclerosis based on updated guidelines
Recent European guidelines have introduced the concept of exercise pulmonary hypertension (ex-PH). However, the clinical characteristics of ex-PH in systemic sclerosis (SSc) remains unknown. We aimed to invest...
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Open AccessGenomic profiles of Japanese patients with vulvar squamous cell carcinoma
The incidence of vulvar carcinoma varies by race; however, it is a rare disease, and its genomic profiles remain largely unknown. This study examined the characteristics of vulvar squamous cell carcinoma (VSCC...
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Open AccessWhole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma
The mechanism underlying the development of tumors, particularly at early stages, still remains mostly elusive. Here, we report whole-genome long and short read sequencing analysis of 76 lung cancers, focusing...
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Open AccessAn ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
Activation of the KRAS oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we show that induction of KRASG12V expres...
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Open AccessContribution of an Asian-prevalent HLA haplotype to the risk of HBV-related hepatocellular carcinoma
Liver cancer, particularly hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), is more common in Asians than in Caucasians. This is due, at least in part, to regional differences in the prevalence ...
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Open AccessGenome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...
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Open AccessComparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts
Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare the genetic backgrounds and their effect on clinical outcomes between Japanese and Caucasian patients with...
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Open AccessPredictive model for the preoperative assessment and prognostic modeling of lymph node metastasis in endometrial cancer
Lymph node metastasis (LNM) is a well-established prognostic factor in endometrial cancer (EC). We aimed to construct a model that predicts LNM and prognosis using preoperative factors such as myometrial invas...
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Open AccessAssociation between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction
We clarified the association between changes in the number of foundational medications for heart failure (FMHF) during hospitalization for worsening heart failure (HF) and post-discharge prognosis. We retrospe...
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Article
Open AccessPhasing analysis of lung cancer genomes using a long read sequencer
Chromosomal backgrounds of cancerous mutations still remain elusive. Here, we conduct the phasing analysis of non-small cell lung cancer specimens of 20 Japanese patients. By the combinatory use of short and l...
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Open AccessPotential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction
Malnutrition is common in patients with heart failure with reduced ejection fraction (HFrEF) and may influence the long-term prognosis and allocation of combination medical therapy. We reviewed 1231 consecutiv...
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Open AccessHigh prevalence of occult left ventricular diastolic dysfunction detected by exercise stress test in systemic sclerosis
Despite the poor prognosis of systemic sclerosis (SSc) due to the co-occurrence of left ventricular diastolic dysfunction (LVDD), presence of occult LVDD has not been sufficiently investigated. This retrospect...
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Open AccessTemporal trends in tolvaptan use after revision of national heart failure guidelines in Japan
Within no definite diuretic protocol for acute heart failure (AHF) patients and its variation in regional clinical guidelines, the latest national guidelines in Japan commends use of tolvaptan in diuretic-resi...
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Open AccessTP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer
Targeted sequencing for somatic mutations across the hotspots of 50 cancer-related genes was performed using biopsy specimens to investigate whether clinicopathological factors and genomic alterations correlat...
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Open AccessDistribution of genetic alterations in high-risk early-stage cervical cancer patients treated with postoperative radiation therapy
Somatic genetic alteration analysis was performed for post-hysterectomy high-risk early-stage uterine cervical cancer patients who underwent post-operative radiation therapy. Post-operative radiation therapy w...
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Open AccessCharacterization of cancer omics and drug perturbations in panels of lung cancer cells
To better understand the disruptions of transcriptional regulations and gene expression in lung cancers, we constructed a multi-omics catalogue of the responses of lung cancer cells to a series of chemical com...
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Open AccessIdentification of potential regulatory mutations using multi-omics analysis and haploty** of lung adenocarcinoma cell lines
The functional relevancy of mutations occurring in the regulatory regions in cancers remains mostly elusive. Here, we identified and analyzed regulatory mutations having transcriptional consequences in lung ad...
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Open AccessCombinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response
Single-cell RNA-seq is a powerful tool for revealing heterogeneity in cancer cells. However, each of the current single-cell RNA-seq platforms has inherent advantages and disadvantages. Here, we show that comb...
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Open AccessA secondary RET mutation in the activation loop conferring resistance to vandetanib
Resistance to vandetanib, a type I RET kinase inhibitor, developed in a patient with metastatic lung adenocarcinoma harboring a CCDC6-RET fusion that initially exhibited a response to treatment. The resistant tum...
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Open AccessMitotic catastrophe is a putative mechanism underlying the weak correlation between sensitivity to carbon ions and cisplatin
In cancer therapy today, carbon ion radiotherapy is used mainly as monotherapy, whereas cisplatin is used concomitantly with X-ray radiotherapy. The effectiveness of concomitant carbon ions and cisplatin is un...
