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Article
Genetic repression of the antioxidant enzymes reduces the lifespan in Drosophila melanogaster
Aging is a biological process associated with gradual loss of function caused by cellular and molecular damages ultimately leading to mortality. Free radicals are implicated in oxidative damage which affects t...
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Article
Natural bioactive 4-Hydroxyisophthalic acid (4-HIPA) exhibited antiproliferative potential by upregulating apoptotic markers in in vitro and in vivo cancer models
There is tremendous scope for identifying novel anti-cancer molecules from the unexplored reserves of plant kingdom. The application of dietary supplementation or medicine derived from such sources is a promis...
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Article
Oxidative stress-mediated cytotoxicity of Endosulfan is causally linked to the inhibition of NADH dehydrogenase and Na+, K+-ATPase in Ehrlich ascites tumor cells
Oxidative stress in cells caused by excessive production of reactive oxygen species (ROS) and decreased antioxidant defense is implicated in the cytotoxicity of xenobiotics including drugs and environmental ch...
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Article
Oxidative stress resistance as a factor in aging: evidence from an extended longevity phenotype of Drosophila melanogaster
Longevity of a species is a multifactorial quantitative trait influenced by genetic background, sex, age and environment of the organism. Extended longevity phenotypes (ELP) from experimental evolution in the ...
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Article
Correction to: Paraquat-Induced Movement Disorder in Relation to Oxidative Stress-Mediated Neurodegeneration in the Brain of Drosophila melanogaster
The original version of this article unfortunately contained a mistake. The entries missing in the reference list are given below and their corresponding citations are provided in the Discussion section text.
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Article
Paraquat-Induced Movement Disorder in Relation to Oxidative Stress-Mediated Neurodegeneration in the Brain of Drosophila melanogaster
Exposure to pesticides like paraquat (PQ) is considered as a risk factor for Parkinson’s disease (PD). PQ has been shown to induce PD-like phenotype in experimental animals. Drosophila, a valuable laboratory mode...
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Article
Sex differences in oxidative stress resistance in relation to longevity in Drosophila melanogaster
Gender differences in lifespan and aging are known across species. Sex differences in longevity within a species can be useful to understand sex-specific aging. Drosophila melanogaster is a good model to study th...
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Article
Neuroprotective Effect of Decalepis hamiltonii in Paraquat-Induced Neurotoxicity in Drosophila melanogaster: Biochemical and Behavioral Evidences
In this paper, we have demonstrated for the first time, the antioxidant and neuroprotective effects of Decalepis hamiltonii (Dh) root extract against paraquat (PQ)-induced oxidative stress and neu...
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Article
14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity
Natural compounds with free-radical scavenging activity have potential role in maintaining human health and preventing diseases. In this study, we report the antioxidant and cytoprotective properties of 14-ami...
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Article
Insecticidal activity of the root extract of Decalepis hamiltonii against stored-product insect pests and its application in grain protection
Root extracts of Decalepis hamiltonii were tested for insecticidal activity against the stored products pests, Rhyzopertha domonica, Sitophilus oryzae, Stigobium pancieum, Tribolium castaneum and Callosobruchus c...
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Article
Causal relationship between Hexachlorocyclohexane cytotoxicity, oxidative stress and Na+, K+-ATPase in Ehrlich Ascites Tumor cells
Role of oxidative stress and Na+,K+-ATPase in the cytotoxicity of hexachlorocyclohexane (HCH) on Ehrlich Ascites tumor (EAT) cells has been studied. HCH caused dose dependent cell death as measured by trypan blue...
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Chapter
Pattern of Inhibition of Acetylcholinesterases in Different Regions of the Brain by Two Organophosphorus Homologues, in Relation to Their Differential Neurotoxicity
Although OP compounds are anticholinesterases their differential in vivo inhibition of acetylcholinesterase (AChE) in the nervous system is poorly understood (Tripathi and Dewey, 1989). Bromophos (BR) and Ethylbr...
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Chapter
Organophosphate-Sensitive Carboxylesterase Isozyme(S) in the Rat Liver
Carboxylesterases (CEs) (EC 3.1.1.1) are known to play an important role in the detoxication of organophosphorus (OP) compounds either by hydrolysing them (A-esterases) or by binding them (B-esteraes) accordin...
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Article
Inhibition of steroidogenic activity in the adrenal cortex of rats fed benzene hexachloride (hexachlorocyclohexane)
Feeding various dosages of benzene hexachloride (100, 250, 750 and 1500 ppm) in the diet to weanling male albino rats for 90 days resulted in marked hypertrophy of the adrenals with large, vacuolated cells in ...
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Article
Rodenticidal poisoning of non-target animals: Acute oral toxicity of zinc phosphide to poultry
